血清维生素D和甲状腺激素概况在男性酒精依赖患者中的关系
Yu Liu1,2,3, Yayun Xu4, Yongmei Wang1,2,5
1Department of Material Dependence, Affiliated Psychological Hospital of Anhui Medical University, Hefei, 230022, China.
BMC psychiatry
|October 24, 2023
概括
维生素D缺乏症在男性酒精依赖患者中很常见. 较低的维生素D水平与改变的甲状腺激素特征有关,特别是自由三甲状腺激素 (fT3).
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 成 药物 药物 药物 药物
背景情况:
- 酒精依赖 (AD) 与医疗并发症有关,包括维生素D缺乏和甲状腺功能障碍.
- 患有阿尔茨海默病的人群中维生素D状况和甲状腺激素概况之间的确切关系尚未得到充分确立.
研究的目的:
- 在被诊断为酒精依赖的男性患者中,研究血清维生素D水平和甲状腺激素概况之间的关联.
主要方法:
- 117名患有AD的男性患者的血清25-氧维生素D [25(OH) D]水平进行了评估.
- 患者被分为正常的维生素D (n=46) 和维生素D缺乏 (n=71) 组,基于25...OH) D <50nmol/L.
- 测量和比较甲状腺激素 (TT3,TT4,TSH,ft3,ft4);使用皮尔森相关性和多变量回归分析了与25(OH) D的相关性.
主要成果:
- 维生素D缺乏症在60.7%的男性阿尔茨海默病患者中流行.
- 与正常维生素D患者相比,维生素D缺乏症患者的TT3,TT4,ft3和ft4水平显著更高.
- 血清维生素D水平与TT3,ft3和ft4呈负相关性;多变量分析证实只有ft3.4的独立关联.
结论:
- 血清维生素D水平与男性酒精依赖患者的甲状腺激素概况显著相关.
- 具体来说,较低的维生素D水平与改变的自由三铁 (fT3) 水平相关,这表明这些情况之间存在潜在的联系.
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