与纤维肌痛患者的大脑体积相关的心理特征
Satoshi Izuno1, Kazufumi Yoshihara2, Masako Hosoi3,4
1Department of Psychosomatic Medicine, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashiku, Fukuoka, Fukuoka, 812-8582, Japan.
BioPsychoSocial medicine
|October 24, 2023
概括
纤维肌痛患者在极的白质体积增加. 女性纤维肌痛患者的大脑变化与焦虑,抑郁和疼痛灾难性有关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 纤维肌痛 (FM) 是一种慢性疼痛疾病,经常伴随着焦虑和抑郁.
- 疼痛灾难化经常在FM患者中观察到.
- 了解FM的神经生物学基础至关重要.
研究的目的:
- 为了研究女性 FM 患者的大脑体积特征.
- 为了探索心理指数 (焦虑,抑郁,疼痛灾难化) 和脑容量之间的关联在FM.
主要方法:
- 结构性MRI (T1加权) 用于比较34名女性FM患者和25名健康对照 (HC) 之间的灰质和白质体积.
- 在FM患者的心理问卷数据 (焦虑,抑郁,疼痛灾难化子尺度) 和大脑体积之间进行了相关性分析.
主要成果:
- 与HC相比,女性FM患者在极中表现出明显更大的白质体积.
- 在特征焦虑和杏仁体灰质体积之间发现了负相关性.
- 观察到抑郁症和脑干白质量之间,以及疼痛放大和中枢环后白质量之间存在积极的相关性.
结论:
- 在女性 FM 患者中,大脑体积的变化,特别是极,杏仁体,脑干和后中心,与心理因素有关.
- 这些发现表明纤维肌痛,焦虑,抑郁和疼痛之间存在神经生物学联系.
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