石化二甲糖化调节雌激素受体表达,以改善OVX诱导的骨质疏松症
Guofang Chen1, Yansong Chen2, Junyi Hong2
1Department of Orthopaedics, Zhejiang Xiaoshan Hospital, Hangzhou, 311200, Zhejiang Province, China. cgf1139@163.com.
Journal of orthopaedic surgery and research
|October 24, 2023
概括
在骨质疏松症模型中,secoisolariciresinol diglucoside (SDG) 通过减少炎症和增强骨形成来改善骨健康. 它通过调节老鼠的雌激素水平和雌激素受体表达来实现这一目标.
科学领域:
- 生物化学 生物化学
- 药理学 药理学是指药理学的学科.
- 骨生物学 骨生物学 骨生物学
背景情况:
- 绝经后的骨质疏松症 (PMOP) 与雌激素缺乏有关.
- 一种植物性雌激素Secoisolariciresinol diglucoside (SDG) 显示出改善PMOP的潜力.
- 在PMOP中调节雌激素受体 (ERs) 的SDG的精确机制需要研究.
研究的目的:
- 为了研究SDG影响雌激素受体 (ER) 表达的机制,在绝经后骨质疏松症 (PMOP) 的老鼠模型中.
- 评估SDG对PMOP骨微架构,病理学和血清标志物的治疗效果.
主要方法:
- 绝经后的骨质疏松症通过卵巢切除 (OVX) 在老鼠中被诱导.
- 鼠被用SDG或拉洛西芬 (RLX) 治疗了12周.
- 分析包括微CT,组织学染色,血清标志物 (E2,IL-6) 的ELISA,以及ERα和ERβ表达的西部斑块/免疫组织化学.
主要成果:
- 在OVX大鼠中,SDG治疗改善了骨矿物质含量 (BMC) 和骨矿物质密度 (BMD).
- SDG减少了大腿部病理性损伤和降低了血清IL-6水平.
- SDG增加了雌激素 (E2) 水平,并恢复了ERα和ERβ的表达,而这些表达被OVX降低了.
结论:
- 在OVX大鼠中,SDG减轻了骨损伤和炎症.
- 通过调节E2和ERs (ERα,ERβ) 表达,SDG促进骨的形成.
- SDG证明了绝经后骨质疏松症的治疗潜力.
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