大肠炎相关的致癌:瘤,免疫细胞和肠道微生物群之间的交叉交叉
Junshu Li1, Yanhong Ji1, Na Chen1
1Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Ke Yuan Road 4, No. 1 Gao Peng Street, Chengdu, 610041, China.
炎症性肠病 (IBD) 可以导致结直肠癌 (CRC). 这篇评论探讨了肠道细胞相互作用和肠道微生物群转变如何驱动IBD相关的CRC,为新疗法提供了洞察力.
科学领域:
- 胃肠道学和瘤学
- 细胞生物学 细胞生物学
- 微生物组研究 微生物组研究
背景情况:
- 结肠直肠癌 (CRC) 是一个全球性的健康问题,排名第三最常见的癌症.
- 炎症性肠病 (IBD),包括性结肠炎 (UC) 和克罗恩病 (CD),是CRC发展的重要危险因素.
- 结肠的稳态依赖于肠上皮细胞 (IEC),肠介质细胞 (IMC),免疫细胞和肠道微生物群的协调功能.
研究的目的:
- 阐明各种肠道细胞在从肠道炎症到结肠炎相关癌症发生过程中的多方面的作用.
- 在IBD相关的CRC发育过程中检查不同细胞类型和肠道微生物群之间的关键交叉声.
- 确定针对细胞相互作用和微生物失生症的潜在治疗策略,用于治疗CRC.
主要方法:
- 本综述综合了有关IBD和CRC细胞动态的现有研究.
- 它分析了IECs,IMCs,免疫细胞和肠道微生物群对疾病发病的贡献.
- 该综述侧重于涉及炎症诱导癌症的细胞间通信网络.
主要成果:
- IEC,IMC,免疫细胞和肠道微生物群之间的失调和异常相互作用是结肠炎相关癌症发生的关键驱动因素.
- 特定的细胞损伤,功能障碍或过度招募有助于导致癌症的炎症级联.
- 肠道微生物群在调节炎症环境和影响癌症进展方面发挥着至关重要的作用.
结论:
- 了解肠道细胞和微生物群的复杂相互作用对于理解IBD相关的CRC至关重要.
- 针对这些细胞和微生物相互作用,为新的治疗干预提供了有希望的途径.
- 本综述强调了包括化疗,向疗法,免疫疗法和微生物疗法在内的潜在策略,用于治疗CRC.
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