ZSCAN4与PARP1相互作用,促进小鼠胚胎干细胞中的DNA修复

相关实验视频

Updated: Jul 12, 2025

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage
10:44

Laser Microirradiation to Study In Vivo Cellular Responses to Simple and Complex DNA Damage

Published on: January 31, 2018

10.3K

Li-Kuang Tsai1, Min Peng1, Chia-Chun Chang1

  • 1Institute of Biotechnology, National Taiwan University, Taipei, 106, Taiwan, ROC.

Cell & bioscience
|October 24, 2023
PubMed
概括

指和含有4 (ZSCAN4) 的SCAN域通过与Poly (ADP-ribose) 聚合酶1 (PARP1) 相互作用来帮助DNA修复. 在小鼠胚胎干细胞中的这种蛋白质-蛋白质相互作用减少了DNA双链断裂,增强了基因组的稳定性.

关键词:
DNA双链断裂,导致DNA双链断裂.在小鼠胚胎干细胞.PARP1 的第一部分.这就是ZSCAN4的意义.

更多相关视频

Laser Micro-Irradiation to Study DNA Recruitment During S Phase07:11

Laser Micro-Irradiation to Study DNA Recruitment During S Phase

Published on: April 16, 2021

4.3K
Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging06:44

Assessment of Global DNA Double-Strand End Resection using BrdU-DNA Labeling coupled with Cell Cycle Discrimination Imaging

Published on: April 28, 2021

4.0K

相关概念视频

Restarting Stalled Replication Forks02:37

Restarting Stalled Replication Forks

DNA replication is initiated at sites containing predefined DNA sequences known as origins of replication. DNA is unwound at these sites by the minichromosome maintenance (MCM) helicase and other factors such as Cdc45 and the associated GINS complex.The unwound single strands are protected by replication protein A (RPA) until DNA polymerase starts synthesizing DNA at the 5’ end of the strand in the same direction as the replication fork. To prevent the replication fork from falling apart,...
5.8K
DNA Damage can Stall the Cell Cycle02:37

DNA Damage can Stall the Cell Cycle

In response to DNA damage, cells can pause the cell cycle to assess and repair the breaks. However, the cell must check the DNA at certain critical stages during the cell cycle. If the cell cycle pauses before DNA replication, the cells will contain twice the amount of DNA. On the other hand, if cells arrest after DNA replication but before mitosis, they will contain four times the normal amount of DNA. With a host of specialized proteins at their disposal,cells must use the right protein at...
9.2K
Long-patch Base Excision Repair01:02

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:
7.0K