在非人类灵长类动物中潜在的黄热病病毒感染的血清学证据,墨西哥东南部
Mónica Salas-Rojas1, Edmilson Ferreira de Oliveira-Filho2, Cenia Almazán-Marín1
1UIM en Inmunología, UMAE Hospital de Pediatría, Centro Médico Nacional "Siglo XXI", Instituto Mexicano del Seguro Social, Ciudad de Mexico, México.
One health outlook
|October 25, 2023
概括
黄热病病毒 (YFV) 可能在墨西哥流传,正如非人类灵长类动物 (NHP) 中发现的抗体所表明的那样. 建议在墨西哥和其他地区进一步监测NHP和蚊子载体中的YFV.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 传染性疾病 传染性疾病
- 流行病学 流行病学
背景情况:
- 关节动物传播的黄病毒,包括登革热病毒 (DENV) 和黄热病病毒 (YFV),对全球健康构成重大风险.
- 在拉丁美洲,YFV主要在森林居住的蚊子和非人类灵长类动物 (NHP) 之间循环,传输历史上没有延伸到巴拿马北部.
研究的目的:
- 在墨西哥东南部的NHP群体中调查包括YFV在内的弗拉维病毒感染的血清学证据.
- 评估以前被认为没有病毒的地区未被发现的YFV循环的可能性.
主要方法:
- 从2012年到2018年使用间接免疫光检测 (IFA) 对30个NHP血清 (黑手蜘蛛,黑) 的血清查.
- 针对一组黄病毒和其他新兴病毒的抗体检测.
- 通过减少斑块的中和试验 (PRNT90) 确认了病毒抗体.
主要成果:
- 53.3%的血清显示出IFA对至少一种弗拉维病毒的反应性.
- 来自墨西哥塔巴斯科的2018年三个黑手蜘蛛血清显示出高YFV PRNT90标位 (平均1:246),表明单型YFV感染.
- 在黑猿血清中,较低的PRNT90标位对Ilheus病毒和西尼罗病毒 (WNV) 表明了额外的弗拉维病毒暴露.
结论:
- 在NHP中存在YFV抗体,表明墨西哥可能存在以前未被发现的YFV循环.
- 加强对NHP和蚊子载体中的YFV的监测对于墨西哥和其他被认为是YFV无害的地区至关重要.
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