在现实的条件下抗微生物检查手套的活动:挑战未得到满足
Eva-Maria Klupp1, Birte Knobling1, Gefion Franke1
1Department for Infection Prevention and Control, Institute for Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20251, Hamburg, Germany.
Antimicrobial resistance and infection control
|October 25, 2023
概括
在现实的医院条件下,光激活抗微生物手套对格拉姆阳性细菌的有效性很小. 由于其在预防感染方面的有效性尚未得到证实,因此不建议使用它们.
科学领域:
- 微生物学 微生物学
- 材料科学 材料科学 材料科学
- 预防感染 预防感染
背景情况:
- 抗微生物表面被纳入感染预防策略.
- 医院中的抗微生物表面的实际有效性仍未得到充分研究.
- 这项研究评估了光激活的抗微生物检查手套,用于对抗阳性微生物的检查.
研究的目的:
- 在模拟现实医院条件下评估光激活检查手套的抗菌活性.
- 为了比较这些手套与常规检查手套的有效性.
- 为了确定针对特定的格拉姆阳性和格拉姆阴性细菌的有效性.
主要方法:
- 使用标准化的实验设置,在干燥,现实的污染条件下测试手套.
- 手套被污染了格拉姆阳性细菌 (Enterococcus faecium,耐甲黄金葡萄球菌) 和格拉姆阴性细菌 (Acinetobacter baumannii).
- 在定量培养之前,受污染的手套被暴露在室内光线 (明亮条件) 或保持在黑暗中 (控制) 10 分钟.
主要成果:
- 光强度超过了制造商的激活限值 (>500 lx).
- 手套没有显示出足够的有效性对抗Acinetobacter baumannii.
- 观察到最小的抗微生物活性 (减小因子<1 log10) 对格拉姆阳性细菌,即使在10分钟的光照后.
- 在黑暗条件下观察到类似的结果,表明光线依赖活动有限.
结论:
- 据称高降解因子 (>4 log10) 对于格拉姆阳性细菌不能在现实条件下复制.
- 活性成分对格拉姆阴性微生物没有有效性.
- 在现实的条件下需要进一步调查;目前不建议使用这些手套,以防止潜在的滥用.
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