计算机断层扫描成像和肺部地面玻璃结节的临床特征≤2厘米,具有微粒状图案
Chen-Ran Guo1, Lin Xu1, Xiao Li1
1Department of Thoracic Surgery, Shandong Provincial Hospital, Shandong University, Jinan, China.
Thoracic cancer
|October 25, 2023
概括
微毛囊性肺腺癌与混合地玻璃结节 (mGGNs) ≤2cm显示出更高的淋巴结转移风险. 电脑图像扫描可以帮助诊断这些侵袭性肺癌.
科学领域:
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 调查成像特征,淋巴结转移和小 (≤2cm) 肺腺癌中的遗传突变,具有微粒状图案和混合地玻璃结节 (mGGNs).
- 在这些特定的肺癌病例中为选择肺段切除建立了精细的基础.
研究的目的:
- 为了分析mGGNs ≤2cm的成像特征.
- 为了比较微粒细胞和非微粒细胞mGGNs之间的淋巴结转移和预后.
- 为了识别与微毛囊性肺腺癌相关的遗传突变.
主要方法:
- 对162个手术切除的肺癌 (≤2.0cm) 的回顾性分析.
- 根据成像特征将mGGNs分为五种类型.
- 淋巴结转移的比较和微毛囊mGGNs和固体结节 (SNs) 之间的预后.
- 对基因突变和分子标记物的TCGA数据库分析.
主要成果:
- 在mGGN病理亚型 (p<0.05) 中,形态成像特征显著变化 (p<0.05).
- 与非微毛囊性mGGNs相比,微毛囊性mGGNs的淋巴结转移率显著更高.
- TCGA数据显示,在微毛囊腺癌中,乳酸跨膜蛋白活性,原转录和纤维细胞EMT得分较高,与生存结果较差相关.
结论:
- 与固体结节 (SNs) 相比,mGGNs ≤2cm 具有微毛囊状图案,具有较高的淋巴结转移风险.
- 计算机断层扫描 (CT) 图像功能是诊断这些高风险肺腺癌的宝贵工具.
- 微毛囊性肺腺癌表现出侵略性行为,其特点是恶性瘤和转移潜力更高.
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