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有 Tribulus terrestris L. 提取物的食补充剂对缺血性中风老鼠表现出保护作用

Wenjun Guo^1,2, Jingxuan Yang¹, Jifeng Wang¹

¹School of Pharmaceutical Sciences, Changchun University of Chinese Medicine, Changchun, Jilin, 130117, China.

Molecular nutrition & food research

|October 25, 2023

概括

Tribulus terrestris (GSTTF) 的粗素通过调节基因表达和抑制关键炎症途径,显示出对缺血性中风的保护作用. 这证实了其作为促进大脑健康的食补充剂的潜力.

科学领域:

神经科学是一个神经科学.
药理学药理学是指药理学的学科.
分子生物学分子生物学

背景情况:

Tribulus terrestris L. (TT) 提取物是一种常见的草药补充剂.
之前的研究表明,TT的粗色素素 (GSTTF) 能预防缺血性中风.
GSTTF的神经保护作用的确切机制尚不清楚.

研究的目的:

阐明GSTTF在缺血性中风中的治疗效果背后的分子机制.
确定受GSTTF治疗影响的特定途径和基因标.

主要方法:

在老鼠大脑组织上采用分子生物学和公正的转录学.
在中脑动脉阻塞 (MCAO) 模型下使用转录学分析了mRNA表达.
鉴定出差异表达基因 (DEGs),以了解治疗效应.

主要成果:

在MCAO后,GSTTF治疗显著降低了C反应性蛋白 (CRP),IL-6 (IL-6) 和离子 (Ca2+) 水平的升高.
在对GSTTF.的反应中确定了61个差异表达基因 (DEGs).
在缺血性中风模型中,GSTTF逆转了异常mRNA表达,可能是通过离子抑制和抑制MyD88/IKK/NF-κB通路.

结论:

这项研究揭示了GSTTF在缺血性中风中的疗效的机制基础.
这些发现扩大了GSTTF的潜在医疗应用.
这些结果支持使用GSTTF作为中风管理的食补充剂.

关键词:

食补充剂是一种食补充剂.在Tribulus terrestris的粗肥素中.缺血性中风中风这些机制的机制.转录组学转录组学是指转录组学.

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Ischemic Stroke l: Introduction

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