不同茶叶活性成分对DSS诱导的大肠炎的改善效应和调节机制
Kang Wei1, Yang Wei1, Yuanfeng Wang2
1School of Agriculture and Biology, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Minhang District, Shanghai 200240, P. R. China.
Journal of agricultural and food chemistry
|October 25, 2023
概括
与其他茶叶成分相比,茶叶多 (TPP) 在治疗结肠炎方面表现出更高的疗效. 通过调节微生物群和线粒体功能,TPP有效地减少疾病活动并改善肠道健康.
科学领域:
- 胃肠病学 胃肠病学
- 药理学 药理学 是一个学科.
- 营养保健品 营养保健品
背景情况:
- 大肠炎是一个严重的健康问题,治疗选择有限.
- 茶叶及其活性成分正在研究其在炎症条件下的治疗潜力.
- 了解茶叶成分的差异性影响对于有针对性的干预至关重要.
研究的目的:
- 为了比较不同茶的活性成分茶多 (TPPs),茶多糖 (TPSs),茶棕 (TB) 和茶氨酸 (TA) 在改善小鼠中酸硫酸 (DSS) 诱导的大肠炎的疗效.
- 阐明最有效的茶叶成分的潜在作用机制.
主要方法:
- 在小鼠中使用DSS诱导大肠炎.
- 将TPPs,TPSs,TB和TA给治疗组进行管理.
- 疾病活动指数 (DAI) 的评估.
- 分析肠道微生物群组成,短链脂肪酸 (SCFA),肠道屏障功能,Nrf2/ARE和TLR4/MyD88/NF-κB P65通路以及线粒体功能.
- 在体外细胞实验中评估抗亡和线粒体保护.
主要成果:
- TPP显著减少了DAI的60.87%,其次是TPS (39.13%) 和TB (28.26%);TA没有显著的影响.
- TPPs,TPS和TB调节了肠道微生物群,增加了SCFAs,并增强了肠道屏障功能.
- TPP和TPS激活了Nrf2/ARE通路,并抑制了TLR4/MyD88/NF-κB P65通路.
- 通过抑制Cytc/Cleaved-caspase-3通路,TPPs表现出最强的抗亡和线粒体保护作用.
结论:
- 与TPS和TB相比,茶叶多 (TPP) 具有更高的抗结肠炎活性.
- TPPs的有效性归因于它们提高Akkermansia丰度和调节线粒体功能的能力.
- TPPs为治疗大肠炎提供了一个有希望的治疗策略.
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