高植物蛋白饮食通过调节肠道微生物群改善了肝脂积累
Shanshan Zhu1, Yawen Zhao1, Ludi Liu1,2
1Guangdong Provincial Key Laboratory of Food, Nutrition and Health, and Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou, 510080, P.R. China.
Molecular nutrition & food research
|October 25, 2023
概括
高植物蛋白饮食 (HPD) 通过抑制胆固醇合成来降低体重并改善脂质谱. 这种饮食变化促进了有益的肠道细菌,增加了12,13-DiHOME,它可以抵抗脂质积累.
科学领域:
- 营养科学 营养科学
- 代谢健康 代谢健康
- 微生物组研究 微生物组研究
背景情况:
- 植物蛋白替代动物蛋白是一种管理异构脂的策略.
- 高植物蛋白饮食 (HPD) 对肝脂质疾病的长期影响尚不清楚.
研究的目的:
- 研究长期HPD摄入对小鼠脂质代谢和肝脂质障碍的影响.
主要方法:
- 缺乏阿波利波蛋白E (apoE-/-) 的小鼠在12周内被食正常蛋白质饮食 (NCD) 或HPD.
- 分析包括体重,能量消耗,血糖控制,血清和肝脂,胆固醇生物合成酶 (SQLE),16SrDNA测序和代谢学.
主要成果:
- 在不影响血糖控制的情况下,HPD降低了体重和增加了能量消耗.
- 通过抑制SQLE表达,HPD改善了血清和肝脂质配置文件.
- HPD增加了Lachnospiraceae家族的丰富度和血清中的12,13-DiHOME水平.
- 12,13-DiHOME抑制了HepG2细胞中的脂质积累和SQLE表达.
结论:
- 富含植物蛋白质的饮食可以缓解超脂血症.
- 这种效应是由微生物增加1213-DiHOME的产生,抑制胆固醇生物合成.
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