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Updated: Jul 12, 2025

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嗅觉球体体积和形态变化在COVID-19患者的嗅觉障碍使用磁共振成像使用的嗅觉障碍
Ayşe Eda Parlak1, Ömer Tarik Selçuk2, Gamze Öztürk Yilmaz2
1From the Departments of Radiology.
Journal of computer assisted tomography
|October 25, 2023
概括
患有嗅觉功能障碍的COVID-19患者的嗅觉球体积和嗅觉深度降低,表明嗅觉通路受到直接损害. 这些测量可以帮助监测嗅觉神经的恢复.
科学领域:
- 神经学 神经学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
背景情况:
- 嗅觉功能障碍 (OD) 是COVID-19的一个常见症状.
- 与COVID-19相关的OD的潜在机制尚未完全理解.
- 嗅球 (OB) 和嗅 (OS) 的形态变化可能与此有关.
研究的目的:
- 调查COVID-19患者OD的OB和OS的形态变化.
- 为了比较COVID-19患者和健康对照之间的OB体积 (OBV) 和OS深度 (OSD).
- 评估OBV和OSD用于检测COVID-19相关的OD的诊断潜力.
主要方法:
- 对31名COVID-19患者的脑部MRI扫描进行了回顾性分析,其中包括OD和35名常态对照.
- 对双边OBV和OSD的测量.
- 由神经放射科医生和耳鼻喉科医生对OB形状的评估.
主要成果:
- 与对照组相比,COVID-19患者的OBV和OSD平均值显著降低.
- 异常形状的产科医生在COVID-19组中更为普遍.
- OBV和OSD在区分患者和对照者方面表现出高灵敏度和特异性,OSD的曲线下面面积值高达0.960.
结论:
- 在COVID-19患有OD的患者中,OBV和OSD降低表明嗅觉神经元通路受到直接损害.
- OBV和OSD测量可以作为监测嗅觉神经恢复的客观生物标志物.
- 这些发现有助于理解COVID-19相关的嗅觉功能障碍的病理生理学.
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