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细菌眼表微生物群与患有猫类疹病毒1型眼表疾病的猫的结果之间的关系

Erinn P Mills¹, Chin-Chi Liu¹, Melanie A Mironovich¹

¹Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.

Veterinary ophthalmology

|October 25, 2023

概括

细菌眼部微生物群影响猫疹病毒1 (FHV-1) 的结果. 较低的多样性和较高的细菌负载与猫的FHV-1眼病恶化相关,这表明微生物组和疾病严重程度之间存在联系.

科学领域:

兽医眼科医生兽医眼科医生
微生物学微生物学
动物健康动物健康

背景情况:

猫疹病毒1 (FHV-1) 是家猫眼表面疾病的常见原因之一.
目表面微生物群在FHV-1结局中的作用尚未完全理解.

研究的目的:

调查细菌眼表面微生物群与患有FHV-1眼病的猫的临床结果之间的关联.
为了比较猫之间的微生物群组成和多样性,改善和恶化结果.

主要方法:

研究了22只患有FHV-1眼病的庇护所猫.
结膜被采集用于16S rRNA基因测序和细菌DNA量化.
根据抗病毒治疗后的临床分数,猫被分为改善结果 (ImpOut) 和恶化结果 (WorOut).

主要成果:

在ImpOut和WorOut组之间观察到细菌微生物群组成的显著差异.
与WorOut组相比,ImpOut组表现出更高的α多样性 (Shannon,Simpson,Pielou指数).
在WorOut组中发现了更高的总体细菌DNA度,而在ImpOut组中发现了更丰富的特定细菌,如猫类GAPDH和Bilophila wadsworthia.

结论:

这项研究强调了眼睛表面微生物群和猫的FHV-1结局之间的显著关系.
较低的细菌物种多样性,增加的细菌负载和特定的细菌简介与FHV-1眼病的不良结果有关.
这些发现表明,眼睛微生物组可能是控制猫的FHV-1的目标.

关键词:

16S rRNA 基因测序的基因测序这是一种抗病毒药物.猫科动物猫科动物猫类疹病毒病毒眼睛的微生物群在实时PCR中进行实时PCR.

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