在良性前列腺增生症的纤维化过程中,激活的补充途径
Junya Hata1, Kanako Matsuoka1, Hidenori Akaihata1
1Department of Urology, Fukushima Medical University School of Medicine, Fukushima, Japan.
良性前列腺增生 (BPH) 与丰富的纤维组织显示了替代和晚补途径的激活. 这些途径与BPH纤维性进展有关,影响尿路症状.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 良性前列腺增生 (BPH) 涉及复杂的纤维化过程.
- 补体通路在BPH纤维化中的作用尚未完全理解.
研究的目的:
- 为了研究在不同组织学类型的BPH纤维化中补体通路的激活.
- 为了将补充成分表达与BPH纤维化和下泌尿道症状相关联.
主要方法:
- 分析了56名BPH患者的组织,分为纤维肌肉和纤维组织.
- 对CD45,C3,B因子和C5b-9进行免疫组织化学染色,以评估炎症和补充激活.
- 组织学发现与国际前列腺症状评分 (IPSS) 问卷的相关性.
主要成果:
- 与纤维肌BPH相比,纤维BPH组织的补充成分C3和C5b-9水平显著更高.
- 在纤维肌群中,炎症细胞透率 (CD45) 较高.
- 在纤维状BPH组中观察到慢流 (IPSS Q5) 的得分更高.
结论:
- 在BPH的纤维化过程中,替代和晚补途径被激活.
- 补充激活,特别是晚期途径,可能会导致BPH中的组织纤维化.
- 这些发现表明,对于管理与BPH相关的纤维化和症状来说,这是一个潜在的治疗标.
更多相关视频
13:18How to Study Basement Membrane Stiffness as a Biophysical Trigger in Prostate Cancer and Other Age-related Pathologies or Metabolic Diseases
Published on: September 20, 2016
08:38Renal Capsule Xenografting and Subcutaneous Pellet Implantation for the Evaluation of Prostate Carcinogenesis and Benign Prostatic Hyperplasia
Published on: August 28, 2013
相关概念视频
Complement System
Accessory Glands of the Male Reproductive System
The epididymis is a small, comma-shaped organ located at the back of each testicle. The epididymis can be divided into three main parts: the head, body, and tail. The head of the epididymis...
Extrinsic and Intrinsic Pathways of Hemostasis
The Extrinsic Pathway
The extrinsic pathway of coagulation is typically initiated by tissue damage that exposes blood to tissue factor (TF), a protein released by the damaged tissue cells outside the blood vessels—this interaction with TF triggers biochemical reactions involving specific clotting factors. The key player here is Factor VII, which...
Antigen Processing Pathways
MHC Class I: Presenting Endogenous...
Clot Retraction and Fibrinolysis
Formation of the Platelet Plug
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...
