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艾滋病毒感染免疫不响应者的严重肠道屏障损伤
Xiao-Yan Guo1,2, Yun-Tian Guo2,3, Ze-Rui Wang4
1Beijing Ditan Hospital, Capital Medical University, Beijing, China.
Heliyon
|October 25, 2023
概括
人类免疫缺陷病毒 (HIV) 患者即使接受治疗,肠道屏障损伤仍然存在,免疫不响应者 (INRs) 比免疫响应者 (IRs) 更严重. 损伤与艾滋病毒DNA相关,与CD4+T细胞计数相反.
科学领域:
- 病毒学 病毒学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 肠上皮屏障对于人类免疫缺陷病毒 (HIV) 疾病进展至关重要.
- 在免疫反应者 (IRs) 和不反应者 (INRs) 中肠道屏障损伤的程度尚不清楚.
研究的目的:
- 为了比较肠上皮质屏障损伤和相关的分子标志物之间的IRs,INRs,和健康的对照 (HCs).
- 调查肠道损伤,艾滋病毒DNA,CD4+T细胞计数和炎症之间的相关性.
主要方法:
- 对肠腺损伤,克劳丁-1,酶-3,艾滋病毒DNA,CD4+T细胞计数和瘤死亡因子-α (TNF-α) 的分析.
- 对IRs (n=10),INRs (n=8) 和HCs (n=7) 的比较.
主要成果:
- 在IR和INR中都存在肠道损伤,在INR中观察到的损伤明显更严重.
- 肠道损伤与艾滋病毒DNA水平正相关.
- 肠道损伤与CD4+T细胞计数负相关.
结论:
- 在接受抗逆转录病毒治疗的HIV患者中,肠上皮质屏障损伤并未完全恢复.
- INRs表现出比IRs更严重的肠壁损伤.
- 肠道屏障完整性与艾滋病毒感染中的病毒载量和免疫状态有关.
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