关节内骨髓单核细胞疗法改善自然发生的马骨关节炎导致的
J Blake Everett1, Bruno C Menarim1,2, Sarah H Barrett3
1Department of Large Animal Clinical Sciences, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, VA, United States.
Frontiers in veterinary science
|October 25, 2023
概括
骨髓单核细胞 (BMNC) 显示出治疗马类关节炎 (OA) 的前景. 这种疗法可以减少和关节胀,没有观察到任何不良影响,这表明可能需要进一步的临床试验.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 再生医学是一种再生医学.
- 马类骨科 马类骨科 马类骨科
背景情况:
- 马的骨关节炎 (OA) 会导致严重的和炎症.
- 目前用于马类骨关节炎的治疗方法提供有限的缓解,并且可能产生副作用.
- 骨髓单核细胞 (BMNC) 具有再生性质,并且在减少炎症和OA症状方面表现出有效性.
研究的目的:
- 评估骨髓单核细胞 (BMNC) 治疗在自然发生性骨关节炎的马中的有效性.
- 评估BMNC治疗对临床症状,,关节周长和突液参数的影响.
主要方法:
- 患有中度单关节性骨关节炎的马被随机分为三组:盐水,氨或BMNC.
- 在基线和注射后7天和21天评估了,关节周长和突液.
- 对细胞计数和细胞因子/生长因子水平分析了共液.
主要成果:
- 在第7天,BMNC治疗导致突液核细胞显著增加.
- 从第7天到第21天,BMNC组观察到关节周长的显著减少.
- 客观的得分在BMNC组在第7天和第21天之间显著改善,没有报告的不良影响.
结论:
- 关节内BMNC治疗是安全有效的,可以改善马类OA的临床症状.
- BMNC治疗减少了和关节胀,支持其作为治疗选择的潜力.
- 需要进一步的临床试验来证实BMNC治疗马类OA的疗效.
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