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Muhammad Faisal^1,2, Nguyen-Son Le³, Stefan Grasl³

¹Department of Surgical Oncology, Shaukat Khanum Memorial Cancer Hospital and Research Center, Lahore, Pakistan.

International archives of otorhinolaryngology

|October 25, 2023

概括

宫淋巴结转移中的p16过度表达是未知初级癌症 (CUP) 中改善无复发生存率 (RFS) 的重要预测因素. 这一发现表明p16阳性可能引导CUP患者的治疗决策.

科学领域:

在瘤学瘤学.
病理学病理学病理学

背景情况:

未知初级癌症 (CUP) 存在诊断方面的挑战.
年龄和淋巴结比率是CUP中确定的预后因素.

研究的目的:

为了评估p16过度表达的预后价值在没有确定的原发性瘤的CUP患者.
确定p16状态是否影响整体存活率 (OS) 和无复发存活率 (RFS).

主要方法:

对43名CUP患者进行治疗性淋巴结解剖 (LND) 的回顾性分析.
免疫组织化学用于评估p16过度表达.
考克斯比例危险回归分析应用于生存数据.

主要成果:

确定p16阳性是区域无复发生存期 (RRFS) 的独立预测因子 (HR 6.180).
复发的中位时间为10个月,死亡的中位时间为25个月.
临床病理学数据,不包括p16状态,并没有显著影响5年的OS或RFS.

结论:

宫转移与p16过度表达表明CUP手术后RFS得到改善.
淋巴结p16的阳性值得进一步调查,作为CUP的预后标志物.

关键词:

头部和部的新生瘤.新生体转移的转移.不知道的初级初级初级

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