城市化与肠道微生物群的多样性受限以及婴儿的成熟延迟有关
Francesco Morandini1, Kevin Perez2, Loic Brot3,4
1Biology department, University of Rochester, Rochester, NY 14620, USA.
iScience
|October 25, 2023
概括
城市生活方式改变了母亲和婴儿的肠道微生物组,增加了疾病风险. 这项研究揭示了与工业化相关的特定微生物变化,影响了塞内加尔的健康结果.
科学领域:
- 微生物组研究的研究.
- 人类健康 人类健康 人类健康
- 环境健康 环境健康
背景情况:
- 肠道微生物组的变化与诸如肥胖,过敏和炎症性肠道疾病等普遍疾病有关.
- 假设后工业化生活方式推动了肠道微生物组的变化,加剧了这些情况.
- 为了理解这些联系,需要在不同程度的工业化中比较肠道微生物组.
研究的目的:
- 为了研究工业化,生活方式和母婴对的肠道微生物组组成之间的关联.
- 确定与塞内加尔城市与农村环境相关的特定微生物组特征.
- 探索工业化对婴儿肠道微生物群成熟和健康的影响.
主要方法:
- 在60对母婴对中对肠道微生物组合的比较分析.
- 在塞内加尔的农村和城市地区进行了两次采样.
- 微生物组数据与母亲健康 (例如体重) 和婴儿健康结果的相关性.
主要成果:
- 与农村母亲相比,城市母亲表现出明显的肠道微生物组概况,其中拉克诺斯皮拉菌和肠杆菌的丰富性增加.
- 城市母亲的超重率更高.
- 城市婴儿表现出肠道微生物组成熟的延迟和对传染病的易感性增加.
结论:
- 工业化和相关的生活方式的变化显著影响母亲和婴儿的肠道微生物组.
- 特定的微生物种群 (Lachnospiraceae,Enterobacter) 与城市环境有关.
- 延迟婴儿微生物组成熟和增加感染风险与城市生活有关,需要进一步调查.
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