需要在SympT的自动化EartF的帮助 (FEAST-HF):一个随机控制的试点试验
Eloisa Colin-Ramirez1, Wendimagegn Alemayehu2, Finlay A McAlister2,3
1Universidad Anáhuac México, Huixquilucan, Mexico.
CJC open
|October 25, 2023
概括
补充症状性心力衰竭患者的白纤维是安全的,耐受性很好,但没有改善关键生物标志物或改变肠道微生物群. 需要进一步的研究来探索纤维纤维.
科学领域:
- 心脏病学 心脏病学
- 胃肠病学 胃肠病学
- 微生物组研究 微生物组研究
背景情况:
- 临床前和观察性研究表明,肠道微生物组在心力衰竭 (HF) 发病过程中起着作用.
- 可发酵食纤维 (FDF) 可能会改变肠道微生物群.
- FEAST-HF试验调查了HF患者的FDF补充剂.
研究的目的:
- 评估招募和补充HF患者使用FDF的可行性.
- 要确定与对照组相比,FDF (树木) 是否降低了NT-proBNP和ST2水平.
- 评估FDF对肠道微生物组合物的影响.
主要方法:
- 随机对照试验,51名患者被分配给微晶纤维素 (MCC),5g/天木瓜,或10g/天木瓜.
- 在基线,6周和12周测量的结果包括NT-proBNP,ST2,NYHA类,生活质量得分和6分钟步行测试.
- 在整个研究过程中,监测了安全性,耐受性和坚持性.
主要成果:
- 在长达12周的时间内,在白和MCC组之间没有观察到NT-proBNP,ST2,NYHA类或生活质量得分的显著差异.
- 饮食补充剂含有秋草显示对肠道微生物群落的影响微乎其微.
- 对于这两种阿卡西亚剂量,没有报告安全性,耐受性或坚持性问题.
结论:
- 饮食补充剂的香草是安全的,并且在门诊HF患者中耐受良好.
- 果补充剂没有显著改变NT-proBNP水平,ST2或肠道微生物组合.
- FEAST-HF试验没有在这个HF人群中证明木的临床益处.
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