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再发性子宫癌的再照射:一个单一的机构经验

Junyun Li¹, Lin Huang¹, Haiying Wu¹

¹Department of Radiation Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center.

Clinical and translational radiation oncology

|October 25, 2023

概括

使用体积调节弧线疗法 (VMAT) 治疗复发性子宫癌的救援放射疗法显示出有前途. 治疗间隔较长和SCC抗原水平较低的患者经历了更好的结果.

科学领域:

辐射瘤学辐射瘤学
妇科瘤学妇科瘤学
医学物理医学物理

背景情况:

在初始放射治疗后复发子宫癌的救生治疗存在重大临床挑战.
再辐射策略对于改善这些患者的治疗结果至关重要.

研究的目的:

追溯分析宫癌患者经过放射治疗的再辐射的临床结果.
评估基于体积调节弧线疗法 (VMAT) 的再辐射的疗效和安全性.

主要方法:

分析了2015-2017年期间接受再辐射的50名患者.
治疗包括单独使用VMAT或使用VMAT与3D图像引导的支臂治疗 (3D-IGBT).
系统化疗是同时或顺序给予的.

主要成果:

三年当地对照,无进展生存率和整体生存率分别为58.0%,38.7%和44.4%.
放射治疗疗程之间的间隔>12个月与更好的局部控制和PFS相关.
较低的血清SCC抗原水平 (<1.5 ng/ml) 与改善的PFS有关.

结论:

用VMAT重新照射为精选的复发性宫癌患者提供了有效和安全的救援治疗选择.
良好的结果与放射治疗疗程之间的较长间隔和较低的SCC抗原水平有关.

关键词:

宫癌是发生在宫癌的原因之一.再辐射辐射的情况.复发情况复发情况拯救疗法是一种救援疗法.

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