莱普调解前列腺干细胞增殖,光滑肌收缩和线粒体功能在良性前列腺增生
Xiaolong Wang1, Linfa Guo1, Guiyong Liu2
1Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, People's Republic of China.
Diabetes, metabolic syndrome and obesity : targets and therapy
|October 25, 2023
概括
发现与肥胖相关的荷尔蒙 - - 丁可以增加前列腺光滑肌的收缩和肌细胞的增殖. 这表明丁可能会恶化良性前列腺激增症 (BPH) 和下泌尿道症状 (LUTS),特别是在肥胖男性中.
科学领域:
- 内分泌学 在内分泌学.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 细胞生物学 细胞生物学
背景情况:
- 瘦素是一种由脂肪细胞产生的激素,在前列腺细胞增殖中起作用.
- 代谢综合征越来越多地与良性前列腺增生症 (BPH) 和下泌尿道症状 (LUTS) 相关.
- 前列腺光滑肌和扩大是BPH/LUTS的关键因素.
研究的目的:
- 为了研究瘦素对人类前列腺的作用,平滑肌肉收缩和树皮细胞生长.
- 探索素在BPH/LUTS病变发生过程中的潜在作用.
- 为了检查莱普对前列腺细胞中线粒体功能的影响.
主要方法:
- 对老鼠前列腺组织进行微阵列分析,以确定与BPH/LUTS进展相关的基因.
- 电场刺激 (EFS) 来评估叶白对人类前列腺光滑肌肉收缩性的影响.
- 细胞增殖和活力测定在人类前列腺侧膜细胞 (WPMY-1) 暴露于勒.
- 线粒体应力测试和流细胞计 (FACS) 来评估细胞亡和线粒体膜潜力.
主要成果:
- 莱普显著提高了人类前列腺 stromal 细胞的增殖率.
- 瘦素增强了人类前列腺的频率依赖性神经性收缩.
- 莱普治疗增加了线粒体膜潜力,并抑制了前列腺 stromal 细胞的亡.
- 微阵列分析表明,素对参与增殖,亡和线粒体代谢的基因进行调节.
结论:
- 莱普刺激人类前列腺光滑肌肉收缩性和树皮细胞增殖,这表明它在BPH/LUTS中发挥了作用.
- 在患有代谢综合征的肥胖个体中,瘦素可能会加剧BPH/LUTS.
- 调节叶素系统可能是BPH/LUTS的潜在治疗策略.
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