益生菌作为系统性红斑狼的补充治疗:一个系统性审查
Zahra Mirfeizi1, Mahmoud Mahmoudi2,3, Arezoo Faridzadeh2,3
1Rheumatology Department, Rheumatic Diseases Research Center Mashhad University of Medical Sciences Mashhad Iran.
Health science reports
|October 25, 2023
概括
益生菌可能有助于控制炎症并改善系统性红斑狼 (SLE) 中的免疫反应. 需要进一步的研究来证实它们作为SLE的辅助疗法的有效性.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 胃肠病学 胃肠病学
背景情况:
- 系统性红斑狼 (SLE) 是一种慢性自身免疫性疾病,病因不明.
- 肠道失生症与SLE的发病有关,它将微生物组与炎症和自我耐受性崩联系起来.
- 益生菌为调节SLE肠道微生物组提供了潜在的治疗途径.
研究的目的:
- 研究益生菌在调节肠道微生物群中的作用.
- 评估益生菌在治疗SLE中的治疗潜力.
- 为未来的SLE管理研究和临床实践提供见解.
主要方法:
- 对2023年6月之前发表的研究进行系统审查.
- 搜索了包括PubMed/MEDLINE,科学网,Scopus和Cochrane图书馆在内的数据库.
- 包括体内,体外和临床试验研究中的益生菌和SLE.
主要成果:
- 确定了22篇关于益生菌对SLE的影响的文章.
- 益生菌在减少炎症和改善SLE患者免疫和代谢概况方面表现出潜在的潜力.
- 在体内研究大多是中高质量的;单一的RCT是高质量的.
结论:
- 益生菌可以作为一种辅助疗法来管理SLE.
- 目前的证据有限,强调需要更多高质量的随机对照试验.
- 进一步的研究是至关重要的,以充分确定益生菌在SLE中的有效性和安全性.
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