儿童复发性闭膜片难以感染的危险因素
Philip Lee1,2, Koorosh Nemati1, Ellen J Silver3
1Department of Pediatrics, Division of Infectious Diseases, Children's Hospital at Montefiore/Albert Einstein College of Medicine.
Hospital pediatrics
|October 25, 2023
概括
在儿童中,复发性Clostridioides difficile感染与慢性疾病有关. 与万科米辛相比,甲尼达的使用与更高的复发率有关,这表明治疗策略对治疗结果产生影响.
科学领域:
- 儿童传染病 儿童传染病
- 流行病学 流行病学
- 临床微生物学 临床微生物学
背景情况:
- 艰难菌感染 (CDI) 是儿童发病率的重要原因之一.
- 复发性CDI (rCDI) 在儿科患者群体中提出了独特的挑战.
- 了解rCDI的风险因素对于有效管理至关重要.
研究的目的:
- 确定与儿童复发性CDI相关的流行病学和治疗因素.
- 分析初始抗生素选择对CDI复发的影响.
- 评估儿科复发性CDI病例中的治疗失败率.
主要方法:
- 一个13年的儿童CDI病例的回顾性审查.
- 确定的早期 (4周2个月) 和晚期 (212个月) 复发.
- 分析了人口,临床和治疗数据,使用双变量和多变量分析.
主要成果:
- 复发性CDI发生在27.4%的儿童中,主要是患有慢性疾病的儿童.
- 女性性别和初始的甲尼达治疗与更高的复发率有关,而不是vancomycin.
- 在患有复发性CDI的儿童中,观察到高治疗失败率33.3%.
结论:
- 潜在的慢性疾病是儿科复发性CDI的关键因素.
- 最初的抗生素选择,特别是甲尼达与万科米辛的选择,可能会影响复发风险.
- 目前的治疗策略对复发性CDI存在局限性,需要进一步研究.
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