丸转移性瘤的起源和结局:一项全国性的研究
Carmen Woortman1, Geert J L H van Leenders2, Niek Hugen3
1Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands.
BJU international
|October 25, 2023
概括
丸转移很罕见,通常从附近的癌症传播. 生存率很差,主要瘤类型显著影响这些不常见的二次丸瘤的结果.
科学领域:
- 在瘤学瘤学.
- 尿道瘤学 尿道瘤学
- 病理学 病理学 病理学
背景情况:
- 丸转移是不常见的二次恶性瘤.
- 了解它们的起源,表现和预后对于患者护理至关重要.
研究的目的:
- 分析丸转移的时间,表现和预后.
- 确定影响二次丸瘤患者结果的因素.
主要方法:
- 对175名病理确认丸转移的患者 (1991-2021) 的回顾性队列分析.
- 数据来源于荷兰全国病理学数据库 (PALGA) 和荷兰癌症登记处.
- 使用卡普兰-梅尔和日志等级测试评估的整体存活率 (OS);使用Cox比例危险模型进行多变量分析.
主要成果:
- 诊断时的平均年龄为67岁.
- 最常见的原发性瘤来源:前列腺 (40.6%),脏 (13.7%),结肠 (10.3%),膀 (7.4%) 和皮肤 (5.7%).
- 在诊断丸转移后的总生存率很差 (中位数为14.2个月);主要瘤起源独立影响了生存率.
结论:
- 丸转移是罕见的,通常来自于解剖学上接近丸的初级瘤.
- 甲基慢性丸转移通常在寡头转移的阶段发现.
- 这些转移与预后不佳有关,受原发性癌症类型的影响.
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