非常老年人的状况及其决定因素:来自纽卡斯尔85+研究的见解
Giorgia Perri1,2, John C Mathers1,2, Carmen Martin-Ruiz3
1Human Nutrition and Exercise Research Centre, Centre for Healthier Lives, Population Health Sciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon TyneNE2 4HH, UK.
The British journal of nutrition
|October 25, 2023
概括
大多数非常老的成年人具有低于最佳的状态,影响蛋白P (SELENOP) 水平. 蛋白质摄入量和其他因素会影响这种人群中的状况.
科学领域:
- 老年学是一门学科.
- 营养生物化学 营养生物化学
- 人类健康 人类健康 人类健康
背景情况:
- 有限的数据存在于非常古老的状态.
- 对抗氧化剂防御和整体健康至关重要.
研究的目的:
- 评估英格兰东北部85岁老人的状况.
- 确定状态的决定因素和生物标志物之间的相互关系.
- 为了比较生物标志物度与已确定的截止值.
主要方法:
- 在757名来自纽卡斯尔85+研究的参与者中测量了血清,Selenoprotein P (SELENOP) 和谷氨过氧化酶3 (GPx3) 活性.
- 使用线性回归和受限立方线来分析决定因素和相互关系.
- 生物标志物度与低于最佳的和缺陷的截止值进行了比较.
主要成果:
- 82%和83%的参与者分别有低于最佳的血清和SELENOP.
- 31%和40%的人血清和SELENOP缺乏.
- 蛋白质摄入量是状况的重要决定因素;其他因素包括性别,BMI和体力活动.
结论:
- 大多数研究的非常老的成年人表现出低于最佳的状态.
- 低状态与减少SELENOP和度有关.
- 饮食中的蛋白质摄入量是影响该年龄组水平的关键因素.
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