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生物相容四分位普卢兰功能化2D MoS2基糖表为内置医疗植入物的抗和抗感染涂层

Shounak Roy¹, Prakash Haloi^2,3, Siva Lokesh B^2,3

¹School of Biosciences and Bioengineering, Indian Institute of Technology Mandi, Kamand, Mandi, Himachal Pradesh 175005, India. j.amit@iitmandi.ac.in.

Journal of materials chemistry. B

|October 25, 2023

概括

一种使用四级普鲁兰功能化MoS2 (MCP) 糖板的新型抗菌涂层有效防止医疗植入物感染. 这种安全的,不浸的涂层显示出对细菌的高效性,并防止体内殖民.

科学领域:

生物材料科学生物材料科学
传染病研究传染病研究
纳米技术纳米技术

背景情况:

医疗植入物容易形成生物膜,导致反复感染和宿主组织损伤.
植入物相关的感染需要先进的策略,如抗菌涂层,以防止并发症.
目前的治疗方法往往在有效性,浸和宿主毒性方面扎.

研究的目的:

为医疗植入物开发一种生物相容,不浸,接触式的抗菌涂层.
为了评估四级普鲁兰功能化MoS2 (MCP) 糖板作为抗菌植入物表面的有效性.
评估开发的MCP涂层的安全性和*in vivo*性能.

主要方法:

通过MoS2.2的四分制普卢兰功能化制造阴离子MCP糖基板.
使用静电相互作用,将MCP糖板涂在多多巴胺修饰的不钢和聚乙烯化物基板上.
在小鼠模型中对*E. coli*和*S. aureus*的抗菌活性,稳定性,浸出,细胞毒性 (*in vitro*和*in vivo*) 和*in vivo*疗效的评估.

主要成果:

该MCP涂层表现出极好的抗菌活性 (>99.5%) 对大肠杆菌和金黄色杆菌.
抗菌效果在30多天内保持稳定,涂层材料没有水.
用MCP涂层的植入物对哺乳动物细胞没有急性或亚慢性毒性,并且成功地防止了细菌殖民 *in vivo*.

结论:

四次性普鲁兰功能化MoS2 (MCP) 糖板为医疗植入物提供简单,安全和有效的抗菌涂层.
形成的涂层显著降低了植入物相关感染的风险.
MCP涂层是提高医疗植入物的安全性和寿命的有希望的策略.

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