招募SWAT干预是否会影响随机对照试验中的参与者保留率? 一个系统的审查
Catherine E Arundel1, Laura Clark1
1York Trials Unit, Department of Health Sciences, University of York, York, UK.
Clinical trials (London, England)
|October 25, 2023
概括
在随机对照试验中招募干预措施的有效性证据有限. 需要进一步的研究来评估这些策略如何影响参与者保留,最大限度地减少研究浪费.
科学领域:
- 临床试验方法论 临床试验方法论
- 医疗保健服务研究 医疗服务研究
背景情况:
- 在随机对照试验 (RCT) 中,有效的招聘和保留策略至关重要.
- 尽管在试验 (SWAT) 中进行了测试干预措施的研究,但对有效策略的高确定性证据仍然很少.
- 招聘干预措施对参与者保留的影响被低估了.
研究的目的:
- 系统地审查RCT招聘干预的证据.
- 评估招聘干预措施是否也会影响参与者留守.
- 确定改善RCT招聘和保留的有效策略.
主要方法:
- 对使用招聘干预措施和评估保留率的RCT进行了系统审查.
- 搜索包括主要的数据库 (MEDLINE,EMBASE,Cochrane图书馆) 和一个SWAT存储库.
- 数据提取由两个独立的审稿人进行.
主要成果:
- 从7815个已识别的记录中包括了10项研究.
- 大多数干预重点是参与者信息 (60%),其次是激励 (20%) 和试验设计/招聘干预 (20%).
- 由于异质性,元分析是不可能的;只有一个研究显示了在招聘信中包含照片的统计学上显著的积极影响.
结论:
- 关于招聘策略,特别是SWAT中评估的招聘策略对参与者保留的影响的证据有限.
- 建议评估招聘干预措施对招聘和留守的双重影响.
- 需要进一步的研究,以尽量减少未来的研究成本和临床试验中的浪费.
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