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从薄水凝层中进行电化学控制的释放

Paulina Gwardys¹, Kamil Marcisz¹, Damian Jagleniec¹

¹Faculty of Chemistry, University of Warsaw, 1 Pasteura, WarsawPL 02-093, Poland.

ACS applied materials & interfaces

|October 25, 2023

概括

研究人员开发了一种新型的热反应性水凝,用于控制药物释放. 该系统使用电化学信号触发模型药物的释放,显示了通过皮肤和可植入的输送系统的前景.

科学领域:

材料科学材料科学材料科学
电化学电化学电化学
生物医学工程生物医学工程

背景情况:

开发先进的药物输送系统对于有针对性和高效的治疗干预至关重要.
电化学响应材料可以精确控制药物释放动力学.
热敏水凝根据温度变化提供可调节的释放配置文件.

研究的目的:

介绍一种新型的电化学控制释放系统,使用热敏水凝.
用于药物复合的功能化聚 (N-异烯胺) 水凝与β-环德林.
为了研究从功能化水凝中释放药物的电化学触发.

主要方法:

在金电极上通过电化学诱导的自由基聚合合成的聚-N-异烯胺-β-环氧 (p(NIPA-βCD)) 水凝的合成.
使用石英晶体微平衡与散射监测 (QCM-D) 和扫描电子显微镜 (SEM) 进行水凝性质的表征.
通过宿主-客人复合和使用循环电压计和光谱计监测电化学释放的铁素修饰罗达B (RdFc) 的加载.

主要成果:

成功合成并将p ((NIPA-βCD) 水凝层附着在QCM电极上.
在水凝中通过宿主-客人相互作用证明了RdFc的积累.
铁素部分的氧化有效地触发了RdFc的释放,释放可以通过应用电极电位来控制.

结论:

开发的p(NIPA-βCD) 水凝系统能够精确地对药物释放进行电化学控制.
该系统在接近人体温度时有效运行,因此适用于生理学应用.
这种电化学触发的释放系统显示了通过皮肤递送药物和体内植入物的巨大潜力.

关键词:

N-异烯烯胺的存在电化学控制释放系统的释放系统包容复杂的包容复杂的包容热敏的薄水凝层是一种热敏的薄水凝层.这是β-cyclodextrins.

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