口腔状细胞癌和口腔潜在恶性疾病:一项拉丁美洲研究
Gerardo Gilligan1, René Panico1, Jerónimo Lazos1
1Oral Medicine Department "A", Facultad de Odontología, Universidad Nacional de Córdoba, Córdoba, Argentina.
Oral diseases
|October 25, 2023
概括
拉丁美洲的口腔状细胞癌 (OSCC) 主要发生 de novo (OSCC-dn),没有口腔潜在恶性疾病 (OPMD) 之前. 观察到OPMD和OSCC特征的区域差异.
科学领域:
- 口腔瘤学 在口腔瘤学
- 流行病学 流行病学
- 牙科医学 牙科医学
背景情况:
- 口腔状细胞癌 (OSCC) 是一个重要的全球健康问题.
- 口腔潜在恶性疾病 (OPMD) 是OSCC的前体,但它们的相关性各不相同.
- 了解拉丁美洲的OSCC和OPMD的流行病学对于有针对性的预防和治疗至关重要.
研究的目的:
- 确定与OPMD相关的OSCC频率与拉丁美洲的OSCC-de novo (OSCC-dn) 相比.
- 分析该地区的OSCC流行病概况和传统风险因素.
- 调查OPMD的区域差异及其与OSCC的关联.
主要方法:
- 在17个拉丁美洲中心进行了回顾性观察研究.
- 包括2705个OSCC病例,分析年龄,性别和OPMD相关性.
- 统计分析使用学生的t测试用于定量变量和千平方用于定性变量.
主要成果:
- 总共分析了2705例OSCC病例,平均年龄为62.8岁;55.8%是男性.
- 吸烟 (53.75%) 和饮酒 (38%) 是普遍存在的危险因素.
- OSCC-dn占病例的81.4%,而连续的OSCC (s-OSCC) 占18.6%. 唇红色SCC显示与OPMD (64.3%) 的相关性更高.
结论:
- 拉丁美洲的OSCC-dn更频繁,临床和病理学特征具有显著的区域差异.
- 白血症是最常见的OPMD,但观察到区域差异.
- 建议进行进一步的前性研究,以阐明这些流行病学模式.
相关概念视频
Assessment of the Mouth
220
A thorough mouth assessment, including inspection and palpation of the lips, gums, tongue, tonsils, uvula, and pharynx, is crucial in detecting potential health issues. Diseases ranging from oral cancer to systemic conditions like diabetes could be identified early through careful oral examination. This article provides a detailed guide on conducting a comprehensive mouth assessment.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
Mouth Inspection
The inspection begins with visually examining the mouth for symmetry, color, and size.
220
Skin Cancer
4.2K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Oral Cavity
755
The oral cavity, or the mouth, is a complex structure in humans that plays a vital role in our day-to-day lives. Its role is not only in chewing and swallowing food; it also plays a role in speech and facial expressions.
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
Teeth: The teeth are the hardest structures in our bodies. Humans have two sets of teeth throughout their lifetime: deciduous (baby) teeth and permanent teeth. Each tooth consists of several parts: the crown (visible part), the root (embedded in the jaw), enamel (hard outer...
755
Barrett Esophagus-II: Clinical Manifestations and Management
168
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
168
Barrett Esophagus-I: Introduction
104
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
104
Oral Hypoglycemic Agents: Biguanides and Glitazones
212
Biguanides, particularly metformin (Glucophage), are insulin sensitizers that enhance glucose uptake, thereby reducing insulin resistance. Unlike sulfonylureas, metformin doesn't prompt insulin secretion, which helps to curb hypoglycemia risk. Metformin is beneficial in treating conditions like polycystic ovary syndrome due to its insulin-resistance reduction capability. The drug's primary action involves curtailing hepatic gluconeogenesis, a significant contributor to high blood...
212


