对于每天使用阿片类药物的紧急患者,根据需要给药阿片类药物剂量
Stine Fjendbo Galili1,2,3, Lone Nikolajsen1,3, Bodil Hammer Bech4
1Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
Acta anaesthesiologica Scandinavica
|October 25, 2023
概括
每天服用阿片类药物的患者在ED时面临不充分的疼痛缓解. 一项研究发现,33%的受试者接受的阿片类药物剂量不足,特别是那些每天使用阿片类药物的患者.
科学领域:
- 疼痛管理研究 疼痛管理研究
- 临床药理学 临床药理学
- 紧急医疗 紧急医疗
背景情况:
- 每天使用阿片类药物的患者在住院期间面临不充分疼痛管理的风险更高.
- 在急诊室 (ED) 入院时调整阿片类药物的剂量需要仔细考虑.
研究的目的:
- 调查每日使用阿片类药物的患者在需要时 (PRN) 服用阿片类药物的足够性,这些患者因疼痛而入院ED.
- 为了确定PRN阿片剂量是否根据患者确定的每日阿片剂量 (DDO) 进行了适当的调整.
主要方法:
- 丹麦阿尔胡斯大学医院每日使用阿片类药物并因疼痛入院ED的患者的前性研究 (2021年2月至6月).
- 主要结局:接受初始PRN阿片类药物剂量
- 二次结局:基于DDO值 (<60 mg/天与≥60 mg/天) 的不充分PRN剂量的分析.
主要成果:
- 在接受PRN阿片类药物治疗的82名患者中,在入院3小时内,33% (27/82) 患者接受的剂量低于其DDO的15%.
- 与DDO<60 mg/day (53.1%对20%) 相比,DDO≥60 mg/day的患者接受不充分的PRN剂量的风险是2.65倍的.
结论:
- 每天使用阿片类药物并带有急性疼痛提交ED的患者有明显的风险接受不充分的PRN阿片类药物剂量.
- 较高的每日阿片类药物剂量与不充分的PRN剂量增加的风险有关,突出需要提高意识和教育.
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