针对住院COVID-19患者的静脉维生素C:两项协调随机临床试验
, Neill K J Adhikari1,2, Madiha Hashmi3
1Department of Critical Care Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
JAMA
|October 25, 2023
概括
维生素C没有改善住院COVID-19患者的结果. 这项研究发现,关键和非关键的患者在无器官支持的几天中受益的可能性很低.
科学领域:
- 危急护理医学
- 传染性疾病
- 营养科学
背景情况:
- 维生素C在治疗COVID-19中的有效性仍然不确定.
- 住院COVID-19患者可能受益于维生素C补充剂.
研究的目的:
- 确定静脉注射维生素C是否能改善住院COVID-19患者的治疗结果.
- 评估维生素C对无器官支持日和存活率的影响.
主要方法:
- 两项协调的随机临床试验涉及危急和非危急的COVID-19患者.
- 静脉注射维生素C或安慰剂每6小时,持续96小时.
- 主要结果:无器官支持日和住院存活率的组合.
主要成果:
- 接受维生素C的重症患者中位数为7天,对照组为10天 (OR,0. 88).
- 在两组中,非危急病患者的中位数为22天 (OR,0. 80).
- 危急病患者的存活率为61. 9%,对照组为64. 6%;非危急病患者的存活率为85. 1%和86. 6%.
结论:
- 维生素C在住院COVID-19患者中改善综合结果的可能性较低.
- 这项研究表明,维生素C不太可能对这些患者有益.
- 可能需要进一步的研究来探索特定的子组或替代治疗策略.
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