在心力衰竭患者中异常负荷的预后影响,心脏衰竭患者有保存的射出分数
Zhe Zhen1,2,3, Manting Choy1,2,3, Bin Dong1,2,3
1Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, PR China.
European journal of clinical investigation
|October 25, 2023
概括
心力衰竭中异常的水平与保存的喷射分数 (HFpEF) 患者显著增加长期死亡率和住院的风险. 这突出了负担作为HFpEF中不良结果的关键预测因素.
科学领域:
- 心脏病学 心脏病学
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 在心力衰竭 (HF) 患者中,异常常见.
- 这些异常与更差的临床结果有关.
- 了解在保留喷射分数 (HFpEF) 的高中所扮演的角色至关重要.
研究的目的:
- 调查异常负担对长期死亡率的影响.
- 评估异常负担对HFpEF医院住院率的影响.
- 为了确定负担是否是HFpEF中的独立预测因素.
主要方法:
- 用现有数据对TOPCAT试验中的1717名参与者的分析.
- 异常负荷的定义是血<135或>145mmol/L的几天.
- 使用多变量考克斯比例危险和时间更新的考克斯回归模型.
主要成果:
- 在41.76%的患者中存在异常的负担.
- 异常高的负担与所有原因死亡率 (1.47),心血管疾病死亡 (1.51) 和HF住院 (1.31) 的风险增加相关.
- 即使考虑到随时间变化的水平,这些关联仍然很重要.
结论:
- 异常的负担是HFpEF中长期死亡率的独立预测因素.
- 在HFpEF中,异常的负荷独立地预测HF住院.
- 针对平衡的干预措施可以改善HFpEF的结果.
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