卡巴胺耐药沙门氏菌类型感染病例,巴基斯坦,2022年
Emerging infectious diseases
|October 25, 2023
概括
巴基斯坦的一种沙门氏菌 Typhi 感染最初对治疗有反应,但后来由于 NDM-5 基因而发展出耐药性. 与美罗烯和胆固醇的联合治疗证明是成功的,突出显示了治疗耐卡巴烯菌株的挑战.
科学领域:
- 传染性疾病 传染性疾病
- 微生物学 微生物学
- 抗微生物耐药性 抗微生物耐药性
背景情况:
- 沙门氏菌导致伤寒发烧,这是一个重大的公共卫生问题.
- 在沙门氏菌中出现抗菌素耐药性的出现,给治疗带来了挑战.
- 碳烯耐药性是细菌病原体日益增长的威胁.
研究的目的:
- 报告一种带有获得的抗卡巴胺耐药性沙门氏菌Typhi感染病例.
- 调查沙门氏菌抗药性的遗传基础.
- 评估对抗卡巴胺耐药型沙门氏菌的治疗策略.
主要方法:
- 临床病例报告和患者病史.
- 对沙门氏菌Typhi分离物的抗微生物敏感性测试.
- 检测碳酶基因,包括NDM-5.
- 评估结合疗法治疗结果.
主要成果:
- 最初的沙门氏菌 Typhi 感染对标准治疗有反应.
- 随后的分离物中含有新德里金属β-乳糖酶5 (NDM-5) 基因,从而产生对卡巴胺的耐药性.
- 静脉注射梅洛与胆固醇结合,成功治疗.
- 患者的感染演变为耐卡巴尼姆的沙门氏菌.
结论:
- 在沙门氏菌Typhi中出现NDM-5碳酶是一个关键的临床问题.
- 组合疗法可能有效治疗耐卡巴因的沙门氏杆菌型病毒感染.
- 持续监测和快速诊断对于打击抗菌素耐药性至关重要.
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