巴转移酶的特异性

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Updated: Jul 12, 2025

Overexpression and Purification of Human Cis-prenyltransferase in Escherichia coli
07:35

Overexpression and Purification of Human Cis-prenyltransferase in Escherichia coli

Published on: August 3, 2017

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Yuchen Zhang1, Keisuke Hamada2, Masayuki Satake1

  • 1Department of Chemistry, Graduate School of Science, The University of Tokyo, Bunkyo, Tokyo 113-0033, Japan.

Journal of the American Chemical Society
|October 25, 2023
PubMed
概括

研究人员设计了转移酶, 这些酶对于的修饰至关重要, 他们成功地修改了这些生物催化剂以进行前所未有的化 (C15),从而扩大了它们的用途.

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Allosteric Proteins-ATCase01:19

Allosteric Proteins-ATCase

Binding sites linkages can regulate a protein's function.  For example, enzyme activity is often regulated through a feedback mechanism where the end product of the biochemical process serves as an inhibitor.
Aspartate transcarbamoylase (ATCase) is a cytosolic enzyme that catalyzes the condensation of L-aspartate and carbamoyl phosphate to  N-carbamoyl-L-aspartate. This reaction is the first step in pyrimidine biosynthesis. UTP and CTP, the end products of the pyrimidine synthesis...
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