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简化基于尿液的方法来检测结核病成年人的里法素暴露不足:一项前性诊断准确性研究

Yingda L Xie¹, Nisha Modi¹, Deborah Handler¹

¹Department of Medicine, Rutgers New Jersey Medical School , Newark, New Jersey, USA.

Antimicrobial agents and chemotherapy

|October 25, 2023

概括

尿液光谱仪准确地预测了结核病患者的里法素暴露不足. 这种简单,具有成本效益的测试有助于优化治疗,通过识别需要剂量调整以获得更好的结果的患者.

科学领域:

药理动力学和治疗药物监测
传染病与微生物学
分析化学分析化学

背景情况:

可变的里法的药理动力学使结核病 (TB) 治疗复杂化,并可能导致不良结果.
建议使用血清药物监测,但比尿液检测更难获得.
尿液光谱对预测成年结核病患者里法素暴露不足的有效性需要进一步验证.

研究的目的:

评估尿液光谱仪在预测成年结核病患者中亚目标利法胺血清暴露 (AUC0-24) 的准确性.
为了比较尿液光谱仪的预测性能与血清里法胺度.
评估糖尿病状况对尿液光谱测量的准确性对利法监测的影响.

主要方法:

接受含有里法的治疗方案的成年结核病患者在24小时内收集了血清和尿液样本.
使用液体染色学-并联质谱法测量里法的血清度.
用苏纳哈拉方法通过光谱测量测量里法的尿液分泌量.

主要成果:

尿液光谱测量准确地确定了利法的子目标AUC0-24在0-4,0-8和0-24小时 (AUC ROCs为0.80-0.84).
预测性表现与2小时血清里法胺度 (AUC ROC 0.82) 相比.
糖尿病状况没有显著影响尿液光谱仪的准确性 (P = 0.67-0.92).

结论:

在剂后4-8小时内对尿中里法的光谱测量是一种简单的,具有成本效益的,预测里法暴露不足的方法.
这种方法提供了通过及时调整剂量来优化结核病治疗的关键信息.
尿液光谱测量为结核病管理中的里法治疗药物监测提供了一种实用方法.

关键词:

颜色测量仪的颜色测量方法药物动力学药物动力学这就是为什么Rifampin是Rifampin.在光谱光度测试中,光谱光度测量.治疗药物监测治疗药物监测结核病是一种肺结核病.

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