杜洛西丁在减少导管相关的膀不适:一个前性,随机,双盲,安慰剂控制的研究
Amrita Rath1, R Reena1, Ghanshyam Yadav1
1Department of Anaesthesiology, IMS-BHU, Varanasi, India.
Urology research & practice
|October 25, 2023
概括
杜洛西丁在手术后显著减少了与导管相关的膀不适. 这项研究发现,在麻醉前口服60毫克的杜洛西丁有效降低了这种常见的术后并发症的发生率和严重程度.
科学领域:
- 麻醉学 麻醉学
- 药理学 药理学是指药理学的学科.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 导管相关的膀不适 (CRBD) 是尿路导管后的一个常见的术后问题,其特点是上阴部不适和排泄的冲动.
- 选择性色胺和上腺素再吸收抑制剂 (SNRIs),如杜洛西丁,已经显示出在管理各种疼痛和不适的条件的潜力.
研究的目的:
- 评估杜洛西丁在预防和减少经过胃肠癌手术的患者与导管相关的膀不适的疗效.
- 为了比较杜洛西丁加拉尼提丁与单独拉尼提丁对CRBD发病率和严重性的影响.
主要方法:
- 一项涉及64名成年患者 (ASA身体状况I-II) 进行选择性胃肠道手术的比较研究.
- 患者被分为两组:D组接受口服杜洛西丁 (60毫克) 加拉尼提丁 (150毫克),C组接受拉尼提丁 (150毫克) 两小时前诱导.
- 导管相关的膀不适在导管后的0,1,2,6小时被评估,并被分类为没有,轻度,中度或严重.
主要成果:
- 与C组相比,D组在所有测量时间点 (P < .05) 显示了与导管相关的膀不适的发生率和严重程度在统计学上显著降低.
- 虽然D组的恶心,头和吐发生率较高,但与C组相比,这些不良反应在统计上并不显著 (P > .05).
结论:
- 在诱导前两小时,口服60毫克杜洛丁有效降低了与导管相关的膀不适的发生率和严重性.
- 杜洛西丁是一种有前途的药理干预措施,用于管理CRBD,具有可管理的副作用概况.
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