在绝经后妇女的宫细胞学讨论
Adriana B Campaner1, Gustavo L Fernandes2
1School of Medical Sciences, Department of Gynecology and Obstetrics, Santa Casa de São Paulo, São Paulo, Brazil - abcampaner@terra.com.br.
Minerva obstetrics and gynecology
|October 25, 2023
概括
绝经后妇女的转化区细胞显著减少,这可能会降低宫癌查敏感度. 建议对这一群体进行高风险的HPVDNA测试,因为其在检测子宫病变时的准确性更高.
科学领域:
- 妇科 妇科 妇科 妇科
- 细胞病理学 细胞病理学
- 在瘤学瘤学.
背景情况:
- 宫形态在更年期发生变化,原因是低雌激素.
- 转化区细胞对于宫癌查至关重要.
- 更年期显著影响子宫上皮和侧膜.
研究的目的:
- 为了比较变化区细胞在绝经前和绝经后妇女中的存在.
- 评估更年期对宫细胞学发现的影响.
- 评估不同绝经阶段的查方法的有效性.
主要方法:
- 1,026,671个宫细胞学试验的回顾性分析.
- 评估2010年1月至2015年12月的数据.
- 转化区细胞在女性<50岁和≥50岁中存在的比较.
主要成果:
- 随着年龄的增长,转化区细胞的显著下降被观察到,特别是在50岁以上的女性中 (35%vs67.5%).
- 虽然在两组中阴性细胞学高 (89.9%对95.3%),但更严重的细胞学结果发生在绝经后.
- 与年龄相关的转化区细胞的减少会影响查准确度.
结论:
- 更年期妇女的转化区细胞数量较少可能会降低宫癌查敏感度.
- 建议进行高风险人类乳头瘤病毒 (HPV) DNA测试,以提高在绝经后妇女中检测宫病变的灵敏度.
- 当HPV检测无法使用时,建议使用局部雌激素化和适当的技术进行细胞学.
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