开发新的基于的放射性追踪剂来检测PD-L1表达和指导癌症免疫治疗
Shiyu Zhu1,2, Beibei Liang1, Yuxuan Zhou1,2
1NHC Key Laboratory of Nuclear Medicine, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi, 214063, China.
European journal of nuclear medicine and molecular imaging
|October 25, 2023
概括
[68Ga]NOTA-IMB和[18F]AlF-NOTA-IMB这两种新的基于的放射追踪剂可以准确地检测被编程细胞死亡-1 (PD-L1) 的表达. 这些标志物可以通过非侵入性地可视化PD-L1水平的动态变化来监测免疫疗法的有效性.
科学领域:
- 核医学是一种核医学.
- 分子成像学分子成像学
- 放射化学 放射化学是指辐射化学.
背景情况:
- 由于瘤异质性,免疫组织化学 (IHC) 在准确检测编程细胞死亡联体-1 (PD-L1) 表达方面存在局限性.
- 定子发射断层扫描 (PET) 为PD-L1表达的视觉,实时和定量评估提供了一种非侵入性方法.
研究的目的:
- 开发基于新型的放射性追踪剂[68Ga]NOTA-IMB和[18F]AlF-NOTA-IMB,用于精确检测PD-L1表达.
- 通过监测PD-L1表达来评估这些标记物的有用性,以指导癌症免疫疗法.
主要方法:
- 用68Ga和18F-AlF对NOTA-IMB的合成和放射性标记.
- 在体外结合测试以确认PD-L1检测能力.
- 在携带瘤的小鼠体内PET成像,以监测PD-L1表达和免疫治疗期间的动态变化.
- 支持分析包括射线自拍,西部涂抹,免疫光学和生物分布.
主要成果:
- 成功制备了具有高放射性化学产量和纯度的[68Ga]NOTA-IMB和[18F]AlF-NOTA-IMB.
- 这两种标志物在体外和体内都显示出高亲和力和对PD-L1的特定结合.
- PET成像成功可视化了瘤中的PD-L1表达,并检测了免疫疗法 (Atezolizumab) 诱导的动态变化.
- 结果与其他验证方法有很好的相关性,显示PD-L1表达在治疗后显著减少.
结论:
- [68Ga]NOTA-IMB和[18F]AlF-NOTA-IMB是用于非侵入性和定量PD-L1成像的有效PET追踪剂.
- 这些辐射追踪器可以在免疫治疗期间灵敏地检测PD-L1表达的动态变化.
- 开发的标记物对准确的PD-L1检测和监测各种癌症的免疫治疗疗效具有前途.
关键词:
18F 18F 18F 18F 18F 18F 18F 18F 18F 18F 18F 18F 18F68GaGa 68GaGaGa 68GaGa 68GaGa 68GaGa 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga 68Ga免疫治疗是一种免疫疗法.基于的放射性追踪剂阳位子辐射断层扫描 (PET)编程细胞死亡连接体-1 (PD-L1)更多相关视频
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