双极和单极抑郁症的代谢生物标志物签名
Jakub Tomasik1, Scott J Harrison2, Nitin Rustogi1
1Department of Chemical Engineering and Biotechnology, University of Cambridge, Cambridge, United Kingdom.
JAMA psychiatry
|October 25, 2023
概括
干血斑块中的新代谢生物标志物签名可以帮助区分双相情感障碍 (BD) 和主要抑郁障碍 (MDD). 将这些生物标志物与患者信息结合起来,可以提高情绪障碍的诊断准确度.
科学领域:
- 在精神病学中发现生物标志物
- 代谢学和质谱学.
- 情绪障碍的差异诊断情绪障碍的差异诊断
背景情况:
- 由于症状重叠,双极性障碍 (BD) 经常被误诊为严重抑郁症 (MDD).
- 缺乏客观的诊断工具阻碍了BD和MDD之间的准确区分.
- 需要可靠的生物标志物来帮助诊断情绪障碍.
研究的目的:
- 在干血斑点 (DBSs) 中识别可复制的代谢生物标志物签名,以便在抑郁发作期间区分BD和MDD.
- 评估这种生物标志物签名在与患者自我报告信息相结合时的诊断附加值.
主要方法:
- 使用来自Delta研究 (英国,2018-2020年) 的样本进行诊断分析.
- 使用向质谱测量对630种DBS代谢物的分析.
- 情绪障碍的诊断通过复合国际诊断面试证实.
- 通过在线问卷 (635个问题) 收集的数据.
主要成果:
- 一个17个生物标志物小组实现了0.71的接收器操作特征曲线 (AUROC) 下的交叉验证面积 (P < .001),其中陶d18:0/24:1作为最强的生物标志物.
- 将生物标志物数据与患者报告的信息相结合,显著提高了诊断性能.
- 生物标志物与终身躁狂症状相关,并在单独的队列中得到验证 (AUROC = 0.73,P < .001).
结论:
- DBS中的代谢生物标志物签名显示了区分BD与MDD的潜力.
- 这项研究提供了一个可访问的生物标志物测试的概念证明,以帮助差异诊断.
- 研究结果表明,胺在情绪障碍的病理生理学中可能发挥作用.
相关概念视频
Bipolar Disorder
68
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
68
Depression: Overview
256
Depression is a prevalent mental illness marked by persistent sadness and lack of interest in previously enjoyable activities. It can take several forms, including major depression, persistent depressive disorder, and bipolar I and II disorders. Symptoms range from emotional changes like chronic worry to physical changes like sleep disturbances and suicidal thoughts. From a neurobiological perspective, depression is believed to be triggered by abnormalities in the brain's prefrontal cortex,...
256
Depressive Disorders: Etiology
104
Depressive disorders result from a complex interplay of biological, psychological, and sociocultural factors, each contributing uniquely to the development and persistence of the condition. Understanding these factors provides critical insight into the multifaceted nature of depression.
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
104
Antidepressant Drugs: MAOIs and Other Agents
254
Atypical antidepressants, including bupropion (Wellbutrin), mirtazapine (Remeron), nefazodone (Serzone), trazodone (Desyrel), and vilazodone (Viibryd), offer unique mechanisms of action. Bupropion weakly inhibits dopamine and norepinephrine reuptake, aiding depression treatment and smoking cessation, with a low risk of sexual dysfunction. Mirtazapine enhances serotonin and norepinephrine neurotransmission, leading to sedation, increased appetite, and weight gain. As a result, it helps treat...
254
Depressive Disorders: MDD and Dysthymia
138
Depressive disorders are a group of mental health conditions characterized by pervasive feelings of sadness, diminished pleasure in life, and a significant impact on daily functioning. These conditions are most prevalent in individuals during their 30s and affect women at twice the rate of men. Contrary to popular belief, younger individuals are generally more susceptible to these disorders than older adults. Two key types of depressive disorders include Major Depressive Disorder (MDD) and...
138
Mania and Antimanic Drugs: Overview
203
Mania, a psychological condition characterized by elevated mood, increased energy, and reduced sleep need, is part of the bipolar disorder cycle. The exact cause of mania isn't entirely known, but it is thought to be a combination of genetic, environmental, and neurological factors. Bipolar disorder involves alternating manic and depressive episodes. Mood stabilizers like lithium, antipsychotics, and anticonvulsants help manage these episodes. Lithium carbonate is particularly effective as...
203


