坦桑尼亚艾滋病毒成年人的长度心电图变化:前性队列研究
Faraan O Rahim1, Francis M Sakita2,3, Lauren Coaxum4
1Duke Global Health Institute, Duke University, Durham, North Carolina, United States of America.
PLOS global public health
|October 25, 2023
概括
使用心电图 (ECG) 进行心血管疾病 (CVD) 查对撒哈拉以南非洲艾滋病毒感染者 (PWH) 至关重要. 在六个月内,超过23%的PWH患者出现了新的心电图异常,表明心血管疾病的快速亚临床进展.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 心血管疾病 (CVD) 患病率在撒哈拉以南非洲 (SSA) 的艾滋病毒感染者 (PWH) 中正在增加.
- 在SSA内的PWH中的纵向心电图 (ECG) 数据有限,尽管ECG在心血管疾病查中的实用性.
- 了解时间心电图变化对于管理心血管疾病风险至关重要.
研究的目的:
- 在坦桑尼亚北部的PWH队列中描述了6个月内ECG变化的发生率和类型.
- 评估接受抗逆转录病毒治疗的PWH新型心电图异常的发生率.
- 为了突出需要在PWH中进行常规心血管疾病查,在SSA.
主要方法:
- 一项前性队列研究涉及476名成年PWH在坦桑尼亚莫希进行.
- 基线和6个月后的随访心电图由两名医生获得并独立解释.
- 新的心电图异常被定义为在基线时缺少的变化,在随访时存在.
主要成果:
- 在基线时,52.1%的参与者有先前存在的心电图异常,最常见的是左心室缩 (LVH) 和T波逆转.
- 在6个月内,23.5%的参与者出现了新的心电图异常.
- 常见的新异常包括T波逆转 (8.0%),LVH (4.6%),ST升高 (2.5%),延长QTc (2.3%).
结论:
- 在坦桑尼亚的PWH中,在短短6个月的时间内,新的心电图异常很常见.
- 这些发现表明,亚临床心血管疾病可能在PWH中在SSA中迅速进展.
- 常规心血管疾病查对于像SSA这样的高风险人群中PWH至关重要.
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