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胆固醇在塑造光滑化 (SMO) 的结构和功能动态中的假定作用

Shweta Kumari1, Abhijit Mitra1, Gopalakrishnan Bulusu1,2,3

  • 1Center for Computational Natural Sciences and Bioinformatics, International Institute of Information Technology, Hyderabad 500032, India.

The journal of physical chemistry. B
|October 25, 2023
PubMed
概括

胆固醇与光滑受体 (SMO) 结合,在其丰富的囊蛋白域 (CRD) 和跨膜域 (TMD) 中,会对其结构和动态产生不同的影响. 这揭示了对SMO-胆固醇相互作用的关键分子洞察力,这对癌症药物开发至关重要.

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