在阿尔茨海默病的血液生物标志物
Pravat K Mandal1,2,3, Joseph C Maroon3, Arun Garg4
1Neuroimaging and Neurospectroscopy (NINS) Laboratory, National Brain Research Centre, Gurgaon 122052, India.
ACS chemical neuroscience
|October 25, 2023
概括
测量氧化压力的新血液测试可能有助于早期发现阿尔茨海默病 (AD). 这种方法可以提供一个具有成本效益的查工具来发现AD的发病,并监测治疗的有效性.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 医学诊断 医学诊断 医学诊断
背景情况:
- 阿尔茨海默病 (AD) 是一种神经退行性疾病,其特征是粉样斑块和团.
- 目前的阿尔茨海默病诊断依赖于侵入性方法或不那么敏感的血液生物标志物,如Aβ42/40和p-tau.
- 氧化应激 (OS) 在AD病理的标志前面,涉及抗氧化剂 (如谷氨 (GSH)) 和金属 (铁,,铜) 的不平衡.
研究的目的:
- 引入与氧化应激相关的基于外周血液的新生物标志物,用于早期发现阿尔茨海默病.
- 探索OS生物标志物的潜力,作为一种具有成本效益的AD查工具.
- 评估OS生物标志物在AD临床试验中监测治疗干预措施的有用性.
主要方法:
- 对外围血液样本进行分析,以确定氧化应激标志物.
- 调查GSH,铁,和铜不平衡在AD病变发生过程中的机制作用.
- 开发和验证与OS相关的生物标志物,用于早期发现AD.
主要成果:
- 周围血液中的氧化应激标记在机理上与AD神经退行有关.
- 谷氨,铁,和铜的不平衡在AD中至关重要.
- 拟议的OS生物标志物显示了早期AD查的潜力.
结论:
- 基于外周血液的氧化应激标志物为早期发现阿尔茨海默病提供了一个有希望的途径.
- 这种方法可以提供一种快速和经济的方法来选AD.
- 在临床试验中,OS生物标志物可以促进对疾病修饰疗法的监测.
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