基于贝他因和聚胺插入的Zwitterionic Micelle作为一个有希望的平台来征服肠粘膜屏障
Kedong Liu1,2, Yun Chen1, Dutao Yang1
1School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China.
ACS applied materials & interfaces
|October 25, 2023
概括
研究人员开发了用于口服药物输送的新型杂交. 这些菌株有效地导航粘液,并增强肠表皮质的药物吸收,显示出提高口服生物利用性的巨大潜力.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术 纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 由于不同的表面特性要求,口服药物递送在平衡粘液透和上皮质吸收方面面临挑战.
- 具有密集,相反电荷的表面的粘液透病毒激发了新的纳米载体设计.
研究的目的:
- 设计和制造一种新的混合菌根平台,用于增强口服药物输送.
- 为了研究菌根的克服粘液和肠道障碍的能力,并改善药物吸收.
主要方法:
- 开发一种基于poly ((carboxybetaine) 和插入polyguanidine的阴离子微粒 (混合微粒).
- 评估杂交细胞的粘液透和上皮吸收特性.
- 对细胞吸收机制的研究,包括聚胺和质子辅助氨基酸载体1 (PAT1) 的作用.
- 细胞内运输通路 (逆行通路) 和细胞转移的分析.
主要成果:
- 优化混合菌体显示出顺序克服粘液和菌壁垒.
- 菌链的长度影响了粘液扩散和细胞吸收.
- 增强的内化吸收与聚胺和PAT1的协同作用有关.
- 逆行路径和细胞转移是细胞内运输的关键机制.
- 观察到显著的 in situ 肠道粘膜吸收和 in vivo 肝脏分布.
结论:
- 开发出的杂交细胞成功克服了口服药物输送的肠道粘膜屏障.
- 这个平台具有很大的潜力,可以通过口服给药药物,口服生物可用性较差.
- 该设计策略为先进的口腔纳米医学提供了一个有前途的方法.
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