临床翻译超极化C二碳酸pH成像方法用于前列腺癌
Changhua Mu1, Xiaoxi Liu1, Yaewon Kim1
1Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California 94107, United States.
ACS sensors
|October 25, 2023
概括
研究人员开发了一种新的超极化碳-13核磁共振 (MRI) 方法,以图像瘤细胞外pH值,使前列腺癌 (PCa) 的更好的检测和风险分层成为可能. 这种pH成像可以作为侵略性疾病的生物标志物.
科学领域:
- 在瘤学瘤学.
- 医疗成像医学成像
- 生物化学 生物化学
背景情况:
- 固体瘤,包括前列腺癌 (PCa),往往表现出酸性瘤微环境 (pH6.5-7.2) 由于诸如 poor perfusion 和高代谢活性等因素.
- 瘤细胞外pH值下降与临床前PCa模型中的疾病进展相关,这表明它有可能作为侵袭性疾病的成像生物标志物.
研究的目的:
- 开发和临床翻译一个超极化碳-13MRI方法用于成像瘤细胞外pH (pHe) 在前列腺癌.
- 建立pH成像作为PCa的检测和风险分层的工具.
主要方法:
- 开发一种基于高极化 (HP) 1,2-糖碳酸盐 (碳-13C) 的MRI方法,用于pHe成像.
- 利用基质催化水解产生HP 13CO32- ,它被转化为HP H13CO3-用于体内给药.
- 克服了临床偏振系统中的偏振损失问题,并为临床应用定制了反应装置.
主要成果:
- 成功生产了一种高度两极化,安全和临床可转换的HP H13CO3-对比剂.
- 临床前研究表明,可靠和准确的测量脏和前列腺瘤酸化.
- 方法支持研究新药应用,为人体试验铺平了道路.
结论:
- 开发的HP 13CMRI方法已经准备好在前列腺癌的人体试验中临床实施.
- 这种pH成像技术有望改善PCa的检测,风险分层和整体管理.
- 图像图像瘤细胞外pH值提供了一个新的生物标志物来评估疾病的攻击性.
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