微粒物质金属组成,氧化潜力和洛杉矶的不良出生结果
Qi Meng1, Jonathan Liu2, Jiaqi Shen3
1Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles (UCLA), Los Angeles, California, USA.
Environmental health perspectives
|October 25, 2023
概括
产前暴露于交通排放,特别是车/轮胎磨损和氧化潜力的金属,增加了早产和低出生体重的风险. 这些风险在少数族裔女性中更高,这表明仅仅减少颗粒物质量是不够的.
科学领域:
- 环境健康科学 环境健康科学
- 生殖流行病学 生殖流行病学
- 毒理学 毒理学 毒理学
背景情况:
- 产前暴露于颗粒物 (PM) 与不利的出生结果有关.
- 对于特定的PM成分及其机制的理解有限.
- 非废气交通排放是一个重要的PM来源.
研究的目的:
- 研究非排气交通排放的氧化潜力和金属元件对早产 (PTB) 和出生时低体重 (TLBW) 的影响.
- 检查特定的污染物,如车和轮胎磨损颗粒.
- 评估氧化潜在标记物的作用.
主要方法:
- 在洛杉矶县 (2017-2019) 使用了285,614个单身婴儿的出生队列.
- 估计的特定颗粒物暴露量,包括制动/轮胎磨损金属 (,),黑碳和氧化潜力标记物 (ROS,OH,DTT).
- 使用后勤回归来评估与PTB和TLBW的关联,按四分位数间范围 (IQR) 的增量.
主要成果:
- 对于金属和氧化潜力指标的IQR增量,PTB (ORs 1.01-1.03) 和TLBW (ORs 1.02-1.05) 的风险增加.
- 关联是强大的,以调整PM质量.
- 在西班牙裔,黑人,混血或美洲原住民女性中观察到更强烈的关联.
结论:
- 暴露于与交通有关的金属和氧化潜在成分会增加PTB和TLBW风险.
- 特别易受伤害的群体包括西班牙裔,黑人,混血或美洲原住民妇女.
- 仅仅减少颗粒物质量可能无法充分保护孕妇和儿童免受与交通有关的暴露.
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