肌肉质量与糖尿病前表现型的关系:基于人群的研究与调解分析
Shanhu Qiu1,2, Xue Cai3, Xiaoying Zhou4
1Department of General Practice, Zhongda Hospital, Institute of Diabetes, School of Medicine, Southeast University, Nanjing 210009, China.
The Journal of clinical endocrinology and metabolism
|October 25, 2023
概括
糖尿病前期肌肉质量降低,即使肌肉质量较高. 升高的HbA1c水平可能表明肌肉质量较差,而不是糖尿病前期血糖水平.
科学领域:
- 内分泌学 在内分泌学.
- 代谢健康 代谢健康
- 肌肉骨健康 肌肉骨健康
背景情况:
- 糖尿病前期增加了身体残疾的风险.
- 肌肉质量是一个关键的功能指标,在糖尿病前期的表型中没有被彻底研究.
- 了解肌肉质量变化对于管理糖尿病前期并发症至关重要.
研究的目的:
- 评估预糖尿病患者的肌肉质量及其在美国一般人口中的特定表型.
- 为了研究糖尿病前期,肌肉质量和潜在的介质 (如胰岛素抵抗) 之间的关联.
主要方法:
- 国家健康和营养检查调查 (2011-2014) 的横截面分析.
- 肌肉质量计算为握力除以手臂肌肉质量 (DXA).
- 参与者按糖尿病前期缺陷分类:孤立 (IFG,IGT,IA1c),双重或所有三种.
主要成果:
- 在糖尿病前期和大多数表型中观察到较低的肌肉质量,尽管握力/肌肉质量更高.
- 肌肉质量下降和低质量的可能性增加与更多的葡萄糖代谢缺陷相关.
- 胰岛素抵抗是主要的调解者; HbA1c定义的前糖尿病显示肌肉质量比葡萄糖定义的前糖尿病更差.
结论:
- 在糖尿病前期及其特定表型中,肌肉质量受到损害.
- 与血糖水平相比,升高的HbA1c可能是肌肉质量下降的更强烈指标.
- 准胰岛素耐药性和监测HbA1c可能对维持糖尿病前期肌肉功能很重要.
更多相关视频
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.6K
07:22Glycemic Impact on Knee Osteoarthritis Symptoms on Physical, Radiographic, and Inflammatory Markers among Individuals Aged 50 and Over with Diabetes
Published on: March 7, 2025
262
相关概念视频
01:22Diabetes Mellitus: Overview and Type I Subtype
2.7K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
2.7K
01:22Diabetes Mellitus: Type 2 and Gestational
2.5K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
2.5K