大电压放射治疗对网状内皮系统器官的影响
Fernando Pereira1, Andy Petroianu2, Jony Marques Geraldo3
1Universidade Federal de Minas Gerais - Departamento de Engenharia Nuclear - Belo Horizonte (MG) - Brazil.
Acta cirurgica brasileira
|October 25, 2023
概括
高能X射线显著降低了库普费尔细胞的体碳吸收,并改变了大鼠的脏巨细胞功能. 这项研究强调了辐射对视网膜内皮系统的影响,影响肝脏和脏功能.
科学领域:
- 放射学和成像学 放射学和成像学
- 细胞生物学 细胞生物学
- 免疫学 免疫学 免疫学
背景情况:
- 网状内皮系统 (RES),包括细胞,如库普弗细胞和巨细胞,在清除外来颗粒从循环中发挥着至关重要的作用.
- 了解放射治疗对RES功能的影响对于管理治疗副作用和优化患者治疗结果至关重要.
研究的目的:
- 研究高能X射线照射对网状内皮系统细胞,特别是库弗弗细胞和脏巨细胞的细胞能力的影响.
- 在大鼠模型中,评估肝脏和脏细胞在腹部辐射后对体碳吸收的变化.
主要方法:
- 维斯塔老鼠被分为对照组和照射组 (8 Gy腹部X射线).
- 体碳被静脉注射在辐射后的24小时和48小时.
- 肝脏和脏组织使用光学显微镜分析了含碳色素的库弗弗细胞和脏巨细胞.
主要成果:
- 照射导致肝脏中含有合碳的库弗弗细胞数量减少.
- 脏在边缘区域显示了缩的合碳吸收,白色和红色纸中的巨细胞的吸收最小.
- 在被辐射的肝脏中观察到肝细胞亡和胆道增殖.
结论:
- 腹部高能X射线照射会损害大鼠库弗弗细胞的体碳吸收能力.
- 辐射暴露会改变脏的细胞分布,并与肝损伤有关,包括肝细胞疾病和胆道变化.
- 这些发现表明,在腹部放射治疗后,网状内皮系统的功能受到重大破坏.
相关概念视频
Biological Effects of Radiation
15.5K
All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they...
15.5K
Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K


