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禁食是否可以保护肝脏免受缺血和再输血损伤?
Marcia Kiyomi Koike1, Denise Frediani Barbeiro1, Heraldo Possolo de Souza1
1Universidade de São Paulo - School of Medicine - Department of Clinical Medicine - São Paulo (SP) - Brazil.
Acta cirurgica brasileira
|October 25, 2023
概括
在肝脏手术前禁食24小时并不能防止缺血/反损伤,并且可能会使大鼠的肥胖症恶化. 在临床实践中,在肝脏手术前长时间禁食可能是禁忌.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 手术研究的研究.
- 胃肠病学 胃肠病学
背景情况:
- 肝脏缺血和再注射 (I/R) 损伤是一个重大的临床挑战.
- 手术前禁食是常见的做法,但它对I / R损伤的影响尚未完全理解.
研究的目的:
- 为了研究24小时禁食期对肝脏缺血症和再注射损伤在老鼠模型中的影响.
- 在肝脏I/R损伤的背景下,评估本地和全身对禁食的反应.
主要方法:
- 成年雄性Wistar大鼠接受了60分钟的肝缺血,随后进行了24小时的再输血.
- 动物被分为两组:对照组 (自由食) 和禁食组 (实验前24小时禁食).
- 评估的参数包括马隆迪甲水平,肝功能测试 (ALT,AST),细胞因子概况 (IL-6,IL-10,TNF-α) 和肝损伤的组织学评估.
主要成果:
- 在禁食组和对照组之间,没有观察到马隆迪甲水平,肝细胞功能或细胞因子水平的显著差异.
- 组织学分析显示,在周门区域有可比的微脉状脂肪.
- 然而,肥胖症在禁食组的缺血性肝叶的第2和第3区域明显明显,与对照组相比.
结论:
- 在老鼠中,24小时的禁食期并不能防止肝脏缺血/反损伤.
- 事实上,在I/R损伤的背景下,禁食可能会加剧肝损伤,特别是脂肪脂肪症.
- 这些发现表明,长时间的手术前禁食可能是有害的,并且在肝脏手术前可能是禁食.
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