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ORFanID:一个基于网络的搜索引擎,用于发现和识别孤儿和分类限制基因

Richard S Gunasekera¹, Komal K B Raja², Suresh Hewapathirana³

¹Department of Chemistry, Physics and Engineering, School of Science, Technology & Health, Biola University, La Mirada, CA, United States of America.

|October 25, 2023

概括

研究人员现在可以很容易地识别所有生命中独特的基因,称为孤儿基因和分类学限制基因 (TRG).

科学领域:

基因组学和生物信息学
进化生物学进化生物学

背景情况:

很大一部分基因在其他种类中缺乏正系基因,称为孤儿基因或分类限制基因 (TRGs).
了解这些独特基因的起源和功能对于进化研究至关重要.
目前用于识别孤儿基因的工具范围有限,使用起来复杂.

研究的目的:

开发和介绍ORFanID,一个用户友好的基于Web的工具,用于识别孤儿基因和TRG.
为了促进在各种分类层面对独特基因的有效和全面的搜索.

主要方法:

ORFanID是一个基于网络的图形搜索引擎,使用DNA或氨基酸序列.
它搜索NCBI数据库和其他生物信息学存储库.
用户可以指定分类学等级和控制NCBI搜索参数.

主要成果:

ORFanID 能够识别任何分类学等级,从物种到领域的独特基因.
结果以可排序的电子表格和交互式图形显示器呈现.
该软件提供过功能和可导航的分类树可视化.

结论:

ORFanID简化了孤儿基因和TRG的识别,克服了以前软件的局限性.
这种工具有助于研究人员研究独特基因的生物起源和进化意义.
促进对基因组多样性和进化进行更广泛的研究.

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