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贝塔氨酸的生物可用性和分泌特征 - - 不同分泌途径之间的可变性和相关性
Yunqing Wang1, Opeyemi O Adekolurejo2, Binying Wang1
1School of Food Science and Nutrition, Faculty of Environment, University of Leeds, LS2 9JT, United Kingdom.
Food chemistry
|October 25, 2023
概括
甜菜贝他林的生物可用性非常低,并且很快被清除. 肠道微生物大量转化这些颜料,影响它们的吸收和新陈代谢.
科学领域:
- 营养科学 营养科学
- 药理动力学 药理动力学
- 微生物组研究 微生物组研究
背景情况:
- 甜菜中的颜料贝塔林 (betalains) 已知具有潜在的健康益处,但它们的生物利用率和代谢命运仍然不太清楚.
- 了解贝他林的转化和分泌对于优化其饮食摄入量和治疗应用至关重要.
研究的目的:
- 调查甜菜消费后人类中贝塔林的生物利用,转化和分泌情况.
- 阐明胃肠道 (GI) 过境和肠道微生物群在贝他林代谢中的作用.
主要方法:
- 在人体中,在食用甜菜后,对脏和便分泌的分析.
- 评估尿液和便中的贝塔林代谢物水平.
- 在GI过境期间评估色素转化,包括脱碳化,脱糖化和脱化.
- 研究结肠发酵及其对贝他林成分的影响.
主要成果:
- 贝塔林的生物利用率非常低,恢复率仅为0.13%和快速排泄 (排泄率常数为0.16h-1).
- 在胃肠道过境期间发生了显著的贝他林耗尽,有证据表明广泛的生物转化.
- 尿中的贝塔胺代谢物水平与便水平呈正相关,突出显示了肠道代谢对生物可用性的影响.
- 在结肠发酵后观察到色素特征的大量个体间和组成差异,这与肠道微生物群的多样性有关.
结论:
- 贝塔素的肠道吸收和系统代谢与它们在肠道内的生物转化密切相关.
- 肠道微生物群在肠道生物转化和随后的贝他林的生物可用性中发挥着关键作用.
- 对肠-贝塔林相互作用的进一步研究是有必要的,以了解它们对健康的影响.
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